IndraLab

Statements

JAK2 leads to the phosphorylation of STAT3 on S727. 3 / 4
| 2 1 1
reach
"Once activated by Jak2, Stat3 is phosphorylated on tyrosine 705 (Tyr705) and serine 727 (Ser727), and the phosphorylation of both amino acid species is required for full Stat3 activity ( Aggarwal et a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24486434
sparser
"Furthermore, treatment of JAK2 clinical medicine AZD1480 to ESCC cells showed similar tendency with Lico B. Thus, JAK2 downstream signaling proteins phosphorylation of STAT3 at Y705 and S727 as well as STAT3 target protein Mcl-1 expression was decreased with treatment of Lico B. Our results suggest that Lico B inhibits ESCC cell growth, arrests cell cycle and induces apoptosis, revealing the underlying mechanism involved in JAK2/STAT3 signaling pathways after Lico B treatment."
32144852
reach
"The phosphorylation of STAT3 at Tyr705 and Ser727 is mediated by the receptor-associated tyrosine kinase JAK2, and both molecules are dephosphorylated by AUY-922 [32]."
34072430