IndraLab

Statements

TP53 binds GSK3B and MDM2. 4 / 4
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"To further confirm this idea, we undertook comprehensive inhibitory approach: we genetically knocked down either MDM2 or GSK-3β with specific shRNA, or inhibited either GSK-3β or MDM2-p53 interaction with small molecule inhibitors."
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"In our co-immunoprecipitation study, we demonstrated that GSK-3β, p53 and MDM2 bind to each other in cytosolic and nuclear fractions of HT-22 cells ( xref )."
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"To study interactions between GSK-3β, p53 and MDM2, we performed co-immunoprecipitation experiments."
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"Taking together, these results demonstrate that GSK-3β inhibition decreases complex formation between GSK-3β, p53 and MDM2 suggesting that GSK-3β activity is essential for interactions between GSK-3β, p53 and MDM2 in subcellular compartments."
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