IndraLab

Statements

Mutated MDM2 inhibits TP53. 5 / 5
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"In agreement with this model, mdm2 mutants defective in p300 but not in p53 binding failed to mediate degradation of p53 and a p53 mutant unable to bind to the N-terminal E6 like domain of p300 was re[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10214351
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"The mutant MDM2 proteins were unable to inhibit p53 dependent transcription in vivo, which is consistent with prior indications that a physical interaction between the two proteins is required for MDM2 's inhibition of p53."
9131587
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"Importantly, the Deltap1-23A Mdm2 mutant interacts with p53 similarly to wild-type Mdm2 (XREF_SUPPLEMENTARY) and degrades p53 as efficiently as wild-type Mdm2 (XREF_SUPPLEMENTARY)."
20708156
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"In the absence of antagonist, p53 function was reduced ~ 90% by wild-type and mutant HDM2."
24278380
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"Thus, it was found that an Mdm2 mutant lacking residues 222-272 also fails to drive p53 degradation, and actually promotes p53 stabilization [88]."
12507556