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IndraLab

Statements

databases
phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach
reading

Mutated MDM2 inhibits TP53. 3 / 3
| 3
reach
"Importantly, the Deltap1-23A Mdm2 mutant interacts with p53 similarly to wild-type Mdm2 (XREF_SUPPLEMENTARY) and degrades p53 as efficiently as wild-type Mdm2 (XREF_SUPPLEMENTARY)."
reach
"In the absence of antagonist, p53 function was reduced ~ 90% by wild-type and mutant HDM2."
reach
"The mutant MDM2 proteins were unable to inhibit p53 dependent transcription in vivo, which is consistent with prior indications that a physical interaction between the two proteins is required for MDM2 's inhibition of p53."