IndraLab

Statements

ABL1 phosphorylates OTULIN on Y56. 4 / 4
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"Consistently, phosphorylation of OTULIN at Tyr56 by c-Abl was also significantly increased in a time-dependent manner upon Dox treatment (Fig.  xref and Supplementary Fig.  xref )."
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"C-Abl phosphorylates OTULIN at tyrosine 56, thereby disrupting its relationship with LUBAC."
35958947
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"Upon genotoxic treatment, DNA damage apical kinase DNA-PK could activate c-Abl which subsequently phosphorylates OTULIN at Tyr56."
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sparser
"All these results indicate that, upon DNA damage, DNA-PK-activated c-Abl phosphorylates OTULIN at Tyr56, which promotes OTULIN association with β-catenin, resulting in β-catenin stabilization and Wnt/β-catenin signaling activation."
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