IndraLab

Statements

CYLD ubiquitinates TRAF6. 10 / 10
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"CYLD also decreased IFN promotor activation by deubiquitinating TRAF2 and TRAF6 in HEK293T cells, respectively [XREF_BIBR, XREF_BIBR]."
31208841
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"On the other hand, over-expression of the H/N mutant CYLD potentiated TRAF-6 ubiquitination ( Fig. 3 C)."
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"In support of this notion, in vivo poly-ubiquitination assays demonstrate that depletion of beta-TRCP impaired TRAF6 self ubiquitination likely due to enhancement of TRAF6 deubiquitination by CYLD, concomitant with a reduction in beta-TRCP-dependent ubiquitination of CYLD and impairment of auto-phosphorylation of TRAF6-downstream kinase IKKalpha."
24961988
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"CYLD negatively regulates NF-kappaB activity by reducing TRAF6 autoubiquitination [XREF_BIBR, XREF_BIBR]."
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"CYLD also decreased IFN promotor activation by deubiquitinating TRAF2 and TRAF6 in HEK293 T cells, respectively [29,30]."
31208841
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"CYLD negatively regulated RANK signaling by inhibiting TRAF6 ubiquitination and activation of downstream signaling events in preosteoclasts XREF_BIBR."
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"Furthermore, CYLD negatively regulated RANK signaling by inhibiting TRAF6 ubiquitination and activation of downstream signaling events."
18382763
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"CYLD can inhibit NF-kappaB activity by deubiquitinating and inactivating TRAF2 and TRAF6, RIP, NEMO, and the NF-kappaB co-activator BCL-3."
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"The deubiquitinating enzymes such as cylindromatosis (CYLD) can inhibit the activation of MyD88 and TRIF dependent NF-kappaB by deubiquitinating TRAF6."
33659012
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"CYLD inhibits RANK signaling by deubiquitinating TRAF6, and CYLD requires the adaptor molecule p62 to interact with TRAF6 [XREF_BIBR]."
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