IndraLab

Statements

UCHL1 activates daf-7. 5 / 5
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reach
"Here, we show that the deubiquitinating enzyme UBH-1 in Caenorhabditis elegans and its human homolog, ubiquitin C-terminal hydrolase-L1 (UCH-L1), stimulate DAF-7 and TGF-beta signaling, suggesting that this mode of regulation of TGF-beta signaling is conserved across animal species."
32371398
reach
"The authors showed that UBH-1 in Caenorhabditis elegans and its human homolog UCHL1 promotes DAF-7/ TGF-β signalling, indicating that the mechanism of TGF-β signalling is conserved among animal species [67]."
34497382
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"These results indicate that UCH-L1 activity supports DAF-7 and TGF-beta signaling and suggest that UCH-L1 's deubiquitination activity is a potential therapeutic target for managing lung cancer."
33516505
reach
"These results indicate that UCH-L1 activity supports DAF-7 and TGF-beta signaling and suggest that UCH-L1 's deubiquitination activity is a potential therapeutic target for managing lung cancer."
32371398
reach
"Here, we show that the deubiquitinating enzyme UBH-1 in Caenorhabditis elegans and its human homolog, ubiquitin C-terminal hydrolase-L1 (UCH-L1), stimulate DAF-7 and TGF-beta signaling, suggesting that this mode of regulation of TGF-beta signaling is conserved across animal species."
33516505