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PKC phosphorylates SCN5A on S1503. 3 / 3
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"Variants in GPD1L have been described as responsible for a loss of enzymatic function resulting in glycerol-3-phosphate PKC-dependent phosphorylation of SCN5A at serine 1503, prominently decreasing sodium current [ xref ]."
32121523
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"PKC dependent phosphorylation of NaV1.5 at S1503 causes alterations in I Na kinetics that open up a window current [XREF_BIBR], and PKC inhibition blocked increased late I Na that was caused by calcium loading the cell [XREF_BIBR], suggesting the invovlement of PKC in CaM pathway causes of late I Na."
26092781
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"Using a heterologous expression system, we show that GPD1L associated with SCN5A and that the BrS- and SIDS-related mutations in GPD1L caused a loss of enzymatic function resulting in glycerol-3-phosphate PKC-dependent phosphorylation of SCN5A at serine 1503 (S1503) through a GPD1L-dependent pathway."
19666841