IndraLab

Statements

TBK1 phosphorylates CYLD. 12 / 12
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"We next investigated if CYLD can be phosphorylated by IKKepsilon or TBK1 in the context of TCR signaling."
29755980
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"Treatment with CYT387 abrogated TBK1 and IKKepsilon induced CYLD phosphorylation in 293T cells, similar to MRT67307 and in contrast to Ruxolitinib (XREF_FIG)."
24444711
sparser
"We next investigated if CYLD can be phosphorylated by IKKε or TBK1 in the context of TCR signaling."
29755980
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"The TCR- and PMA/I induced Ser418 phosphorylation of CYLD could be completely prevented by dual inhibition of IKKepsilon and TBK1, using MRT67307, while the IKKbeta inhibitor TPCA1 had no effect."
29755980
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"However, the precise mechanism that controls the balance between TRIM25/RNF135-mediated ubiquitination and CYLDmediated deubiquitination of RIG-I and the phosphorylation of CYLD by TBK1 in its inhibitory function remains to be elucidated."
32215003
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"Interestingly, TBK1 or IKKε specifically causes CYLD to shift to higher molecular bands, suggesting phosphorylation of CYLD by these kinases."
32215003
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"To examine whether TBK1 and IKKi dual inhibitors suppress CYLD phosphorylation, SCC-9 cells were treated with different TBK1 and IKKi dual inhibitors for 1 hr, and cells were collected for western blot."
24150799
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"However, the precise mechanism that controls the balance between TRIM25/RNF135-mediated ubiquitination and CYLDmediated deubiquitination of RIG-I and the phosphorylation of CYLD by TBK1 in its inhibitory function remains to be elucidated.In addition to the mechanisms mentioned above, several proteins have been described as regulators in TLR-and RLR-mediated signaling."
32215003
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"CYLD phosphorylation can be pharmacologically reversed by IKK inhibitors, specifically by TBK1/IKKepsilon and IKKbeta inhibitors (MRT67307 and TPCA)."
32024820
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"Intrigued by the faster inactivation of CYLD in P1 and P2 ( xref ), we probed the possibility that TBK1 and IKKε phosphorylate CYLD ( xref ; xref ), and assessed the contribution of that interaction to RCD."
34363755
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"We found that transfected TBK1 and IKKε phosphorylate transfected CYLD in a 293T overexpression system, whereas the kinase-dead TBK1-K38A did not ( xref , xref )."
34363755
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"CYLD is phosphorylated by TBK1 to restrain the pro-death propensity of RIPK1 xref ."
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