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USP6 activates Chemokine. 4 / 4
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"USP6 synergistically enhances chemokine induction upon IFN treatment in vitro We previously reported that USP6 not only induces an IFN gene signature by itself , but that it also magnifies the response to exogenous Type I and II IFNs ( 17 ) ."
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"USP6 synergistically enhanced chemokine production in response to exogenous IFN by inducing surface upregulation of IFNAR1 and IFNGR1 ."
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"Among the genes with the greatest synergistic induction were ligands for CXCR3 and CCR5 : USP6 or IFNalpha individually led to modest increases in levels of these chemokines , whereas expression was increased 2-4 orders of magnitude in USP6-expressing cells treated with IFNalpha ( Supplemental Figure 3B ) ."
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"We tested a range of IFNgamma doses and found that USP6 amplified chemokine expression at all doses : at a low dose of 0.5 ng / ml , IFNgamma had no effect on control RD-ES cells , but induced a 10,000 - fold increase in CXCL10 and 100-fold increase in CCL5 expression in USP6 / RD-ES ( Figure 1B ) ."
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