IndraLab

Statements


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sparser
"Thus, we proposed that KH1 domain of PCBP1 specifically binds to stem-loop I and IV of EV71 5′UTR, which may play an important biological function in viral replication."

sparser
"Our results revealed that break of PCBP1 KH1 domain apparently mitigated p27 protein expression and the reporter activity, but not the KH2 and KH3 mutations, indicating that PCBP1 binds to p27 mRNA mainly through its KH1 domain, rather than KH2 and KH3 domains, which is consistent to that PCBP1 KH1 domain interacts with stem-loops I and IV of EV71 5’UTR, facilitating viral replication [ xref ]."