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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

IGF1R binds IRS1 and PPP1R12A. 1 / 1

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"Indeed, previous studies found that PPP1R12A interacted with insulin receptor substrate 1-insulin-like growth factor 1 receptor (IRS1-IGF1R) complex and mediated the process of IRS1 dephosphorylation, promoting PI3K/AKT cascade activation and in turn led to tumor cell proliferation and tumor growth xref , xref ."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...