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Statements

CBL binds EGF and EGFR. 8 / 8
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"A further immuno-coprecipitation assay was conducted to examine the binding of EGFR and c-Cbl and EGF, but not anisomycin, induced the EGFR binding to c-Cbl (D)."
19138820
sparser
"EGF-induced c-Cbl-EGFR binding was partially inhibited, and receptor ubiquitination was abrogated in cells expressing Y1045F-EGFR."
14627991
sparser
"Co-immunoprecipitation studies demonstrated that Cbl became associated with the EGF receptor in an EGF-dependent manner."
8662998
sparser
"Upon EGF binding, EGFR undergoes rapid phosphorylation, internalization and ubiquitination by the E3 ubiquitin ligase Cbl, which targets it for lysosomal degradation [ xref ]."
29920512
sparser
"In order to determine the role of c-CBL in differential degradation of EGFR mutants, we assessed EGFR and c-CBL binding, the effect of c-CBL knockdown on steady state levels of EGFR and c-CBL's effect on EGF and erlotinib-induced EGFR degradation (Figure xref )."
27612423
sparser
"EGF was unable to induce ubiquitination of the serine-mutated EGFR, yet EGF-induced phosphorylation of the c-Cbl-binding site at tyrosine 1045, and c-Cbl-EGFR association, was unaffected."
14627991
sparser
"Further, c-Cbl associates only with EGF-EGFR homodimers, but not with EGF-EGFR/HER2 heterodimers, HER2, HER3, or HER4 ( Levkowitz et al., 1996 ; Muthuswamy et al., 1999 )."
14507736
sparser
"The EGF-dependent rapid association of Cbl with the autophosphorylated EGF receptor observed in some [46, 49–54, 56, 57] , but not all [55] , studies is apparently mediated by the N-terminal region [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9720760