IndraLab

Statements

UCHL1 activates LTP. 7 / 7
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"Since decreased UCH-L1 activity is associated with several neurodegenerative disorders, and pharmacological inhibition of UCH-L1 activity substantially reduces LTP, we assessed any structural alterations to synapses in UCH-L1-inhibited neurons."
19535597
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"These results indicate that Usp14 and Uch-L1 are dispensable for induction of LTP at CA3-CA1 hippocampal synapses."
18771733
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"The hippocampal slices from the nm3419 mice showed a similar strong enhancement of synaptic activity that also lasted over 1 h (XREF_FIG), indicating that loss of Uch-L1 does not impair LTP induced by theta burst stimulation."
18771733
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"5 Furthermore, UCH-L1 activity modulates LTP in hippocampus and is deficient in a mouse model of AD."
26539913
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"A recent study has demonstrated that pharmacological inhibition of UCH-L1 activity by 40% is sufficient to significantly attenuate LTP in rat hippocampal slices."
19535597
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"We have shown : (i) a reduction of soluble Uch-L1 protein levels in the hippocampus of APP and PS1 mice; (ii) that inhibition of Uch-L1 activity leads to the inhibition of hippocampal LTP; and (iii) that transduction of Uch-L1 protein restores LTP in APP and PS1 mice and also reestablishes normal Uch activity, basal neurotransmission and synaptic plasticity, and improves associative memory in mice."
22891628
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"Pharmacological inhibition of UCH-L1 impairs LTP, whereas its overexpression can rescue cognitive function in an AD mouse model, however the mechanism is far from being elucidated."
29867359