IndraLab

Statements

USP9X increases the amount of CTNNB1. 3 / 3
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"Mechanically, USP9X promotes HCC cell proliferation by regulating the expression of beta-catenin."
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"USP9X has also been reported to increase the levels of beta-catenin, a transcription factor linked to the growth of brain tumors XREF_BIBR, XREF_BIBR, and overexpression of USP9X has been reported to enhance the half-life and expression of beta-catenin in mouse L cells and MCF7 cells, respectively XREF_BIBR, XREF_BIBR."
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"However, in contrast to previous studies, which indicated Usp9x positively regulates beta-catenin protein levels, significantly increased pbeta-catenin33/37/41 and Tyr654 pbeta-catenin levels observed in Usp9x -/Y neocortices implied a novel regulatory mechanism in NPs."
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