IndraLab

Statements

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"Our cell model data together with Xue’s data (35) have clarified that USP5 promotes the proliferation and metastatic malignant biological behaviors of NSCLC cells, thus providing a plausible explanation for the contribution of high level of USP5 to poor prognosis of NSCLC.As a member of the USP family, USP5 has been found to cleave both linear and branched ubiquitin polymers, and regulates protein ubiquitination, stability, and function (24,36)."
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"The above results showed that USP5 could promote NSCLC cell proliferation via upregulating the CCND1 protein level through deubiquitylation and stabilization of CCND1."
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"In HCC cells, USP5 knockdown inhibited cell proliferation, migration and drug resistance, while induced apoptosis and activated p14 -p53 signaling [16]."
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"The experimental findings revealed that Degrasyn, an inhibitor of USP5, significantly impeded the proliferation, invasion and EMT progression of bladder cancer cells in vitro.However, the present study has certain limitations."
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"As ubiquitin-specific peptidase 5 has been shown to promote ovarian cancer cell proliferation, 2c can represent a possible new treatment for EOC [30]."
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"Overall, these data demonstrate that USP5 promotes CCA cell proliferation in vitro.In order to further examine the influence of USP5 on CCA cell migration, experiments involving wound-healing and tran[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, the colony formation assays also showed that USP5 knockdown inhibited proliferation of PANC-1 and SW1990, two PDAC cell lines.To further evaluate the role of USP5 in PDAC progression, six[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Knockdown of USP5 has been found to inhibit proliferation of various cancer cell lines [37,193]."
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"The cells treated with USP5 OE and siHDAC2 showed the similar expression levels of HDAC2 and p27 as those treated with Vector and control siRNA (siNC), indicating that USP5 down-regulated p27 expression via regulating HDAC2.Further, CCK-8 (Figure 4G) and flow cytometry analyses (Figure 4H) showed that HDAC2 knockdown partially abrogated cell proliferation promoted by USP5 overexpression."
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"These data indicated that USP5 promoted ovarian cancer cell proliferation and cell cycle progression through regulating HDAC2."
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"By decreasing CCND1 ubiquitination, USP5 stabilizes and upregulates its protein level and consequently promotes NSCLC proliferation."
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"USP5 overexpression enhanced, whereas USP5 silencing impaired the cell proliferation and colony formation of NSCLC cells in vitro."
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"However, the regulation of GPX4 by USP5 needs to be explored.In this study, we found that USP5 deficiency inhibits the proliferation of T24 bladder cancer cells."
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"This suggests a potential biological role for USP5 in CCA.In this study, we present evidence demonstrating that USP5 accelerates CCA progression by facilitating cell proliferation, migration, and epit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"It has been reported that USP5 promotes tumor proliferation and tumorigenesis through the deubiquitination of histone deacetylase 2 (HDAC2) and beta-catenin."
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"USP5 Deficiency Inhibits Cell Viability and Proliferation."
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"Similarly, ubiquitin-specific peptidase 5 (USP5) was significantly upregulated in EC tissues, whereas its inhibition could reduce the migration and proliferation ability of EC cells and induce cell cycle arrest and apoptosis."
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"Some studies have shown that USP5 promotes the proliferation of EOC cells by HDAC2 deubiquitylation [18], and silencing HDAC2 increases the sensitivity of ovarian cancer cells to cisplatin [19]."
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"USP5 knockdown and overexpression inhibited and promoted the proliferation and colony growth of AML cells, respectively."
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"Our study focused on the role of USP5 in bladder cancer and its mechanism, aiming to provide new ideas and targets for the treatment of bladder cancer.Our results demonstrated that USP5 deficiency significantly inhibits the proliferation and colony formation of T24 bladder cancer cells."
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"USP5 knockdown suppressed cell proliferation, migration, and drug resistance and induced apoptosis, while USP5 overexpression promoted colony formation, migration, drug resistance, and tumorigenesis (21)."
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"The ability of USP5 to increase cell proliferation may be attributed to its role in stabilizing key proteins involved in cell cycle regulation and apoptosis."
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"By establishing USP5 overexpression in the MM.1S cell line and silencing USP5 in the NCI-H929, U266 and INA-6 cell lines, we demonstrated for the first time that USP5 effectively promoted MM cell proliferation and metastasis, glycolysis, and lactate formation, corroborating the findings of Peng et al. [23]."
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"The aforementioned experimental results indicate that, in bladder cancer cells, USP5 enhances the proliferation, invasion and EMT process of tumor cells, mainly through SLUG."
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"23, 24, 25 NSCLC studies have shown that high expression levels of USP5 and USP7 in lung cancer tissue promote lung cancer cell proliferation by stabilizing beta-catenin."
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"It was previously reported that USP5 promotes HCC progression by stabilizing SLUG , while USP39 interacts with ZEB1 and regulates HCC proliferation ."
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"Specifically, overexpression of USP5 enhances the proliferation, migration, and EMT of CCA cells."
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"HDAC2 knockdown partially abrogated USP5-promoted ovarian cancer cell proliferation."
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"USP5 knockdown has been found to inhibit the proliferation of various cancer cell lines, except glioblastoma cells [ 13 ]."
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"Overexpression of USP5 accelerates the proliferation of glioblastoma cells, which is abrogated by knockdown of FOXM1."
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"We concluded that USP5 promoted the proliferation of trophoblast cells via the up-regulation of the Wnt and beta-catenin signaling pathway."
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"Cell proliferation assay and colony formation assay were used to verify the effect of EOAI on the proliferation of NSCLC cells, which showed the inhibition of USP5 caused profoundly reduced proliferation of NSCLC cells (Fig. 1D)."
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"It has been reported that USP5 is highly expressed in NSCLC and USP5 silencing inhibited NSCLC cell proliferation and induced cell apoptosis, cell autophagy, and cisplatin sensitivity."
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"13 Our results showed that USP5 silencing enhanced DDP sensitivity, induced cell apoptosis, and inhibited cell proliferation, invasion, and cancer cell stemness."
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"Further studies found that USP5 depletion reduces cell proliferation, invasion and the EMT in bladder cancer cells, and ectopic expression of Twist1 rescues the adverse effects of USP5 loss on cell invasion and the EMT."
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"USP5 was recently found to stabilize c-Maf protein and promote myeloma cell proliferation and survival XREF_BIBR."
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"Our previous studies demonstrated that the deubiquitinase USP5 stabilizes c-Maf and promotes myeloma cell proliferation and survival; therefore, the USP5 and c-Maf axis could be a potential target for myeloma therapy."
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"In vitro, USP5 overexpression promotes the proliferation and migration of EJ bladder cancer cells."
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"USP5 is up-regulated in pancreatic cancer tissue and promotes cell viability and proliferation."
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"USP5 is overexpressed in colorectal cancer tissues and promotes colorectal cancer cell proliferation and resistance to chemotherapeutics."
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"2.1 USP5 Promotes RP Resistance and Malignant Proliferation in GIST."
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"Overall, the presented data substantiate that USP5 promotes malignant proliferation and contributes to RP resistance in GIST cells.2.2 TRIM21 Interacts with USP5 and Decreases its Stability."
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"USP5 deficiency inhibits cell proliferation and migration."
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"Deubiquitinase USP5 promotes non-small cell lung cancer cell proliferation by stabilizing cyclin D1."
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"However, overexpression of RACK1 or USP5 effectively rescued this inhibitory effect, restoring cell proliferation to near-control levels."
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"USP3 was manifested to promote lung cancer growth through upregulating RBM4 via acting as a DUB [30], and USP5 contributed to cell proliferation via stabilizing cyclin D1 protein level in lung cancer [31]."
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"Further functional investigation also showed that Usp5 knockdown suppressed cell proliferation, migration, drug resistance and induced apoptosis; on the other hand, Usp5 overexpression promoted colony formation, migration, drug resistance and tumorigenesis."
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"USP5 overexpression is regulated by EBF transcription factor 1 (EBF1) and contributes to the growth and proliferation of CRC cells [ 49 ]."
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"Knockdown of USP5 in UM1 and SCC9 cells significantly decreased cell proliferation, as indicated by reduced colony formation compared with controls."
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"The siRNA induced knockdown of Usp5 inhibited cell proliferation, migration ability and drug resistance."
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"In MM, knockdown of USP5 can suppress MM cell proliferation and survival, inducing apoptosis [20–22], suggesting that USP5 may be a key factor in promoting MM development."
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"Moreover, in non-small cell lung cancer, USP5 acts as a deubiquitinase, promoting cancer cell proliferation through the stabilization of cyclin D1 (15)."
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"Disruption of USP5 profoundly repressed cell proliferation by inducing cell cycle G0/G1 phase arrest in ovarian cancer cells."
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"CCK-8 assay and colony formation experiments showed that overexpression of USP5 in Panc1 cells dramatically increased the proliferation."
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"Overexpression of USP5 promotes cell proliferation and migration."
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"The colony formation and cell proliferation assay results showed that exogenous overexpression of USP5 increased colony numbers and cell proliferation, but overexpression of USP5 C335A did not have the same effects (Fig. 2B, C)."
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"Taken together, these results suggested that USP5 could evidently promote pancreatic cancer cells proliferation and metastasis."
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"As shown by the CCK-8 assay, A549 and H1299 cell proliferation was promoted by the overexpression of USP5 but impaired by its knockdown (Figure 3D,3E)."
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"Inhibition of USP5 activity suppresses NSCLC cell proliferation in vitro and tumor growth in vivo."
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"These results suggest that pharmacological inhibition of USP5 significantly suppresses the proliferation, invasion and EMT process of bladder cancer cells."
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