IndraLab

"Recently, several additional SUMO proteases have been identified, DeSumoylating Isopeptidase 1 and 2 (DeSI1 and DeSI2; Shin et al., xref ) and USPL1 (Ubiquitin-Specific Protease-Like 1; Schulz et al., xref )."

"Although the full name of DESI2 is desumoylating isopeptidase 2, no experimental evidence showed that it really has activities of desumoylating isopeptidase."

"Under the action of the de-SUMOylation enzymes (sentrin/SUMO-specific protease [SENP] or deSUMOylating isopeptidase [DESI]), the SUMO molecule dissociates from the protein and re-enters SUMOylation cycling.[ xref , xref ]SUMOylation modification can regulate the expression of SERCA2a at the transcriptional and protein levels.[ xref ]Overexpression of SUMO1 but not SUMO2/3 improves the activity of SERCA2a and cardiac function.[ xref xref xref ]"

"In the present work, desumoylating isopeptidase 2 is identified as an antigenic gene of T. bryosalmonae in brown trout."

"We also identified the following 6 genes as being co-expressed with the lncRNAs: myosin IG ( MYO1G ), translocase of inner mitochondrial membrane 29 ( TIMM29 ), co-activator associated arginine methyltransferase 1 ( CARM1 ), adhesion G protein-coupled receptor B1 ( ADGRB1 ), septin 4 ( SEPT4 ), and desumoylating isopeptidase 2 ( DESI2 )."

"Moreover, two additional SUMO isopeptidases have been described in humans, deSUMOylating isopeptidase (DeSI), and the ubiquitin-specific protease-like 1 (USPL1) ( xref ) [ xref ]."

"DeSUMOylating isopeptidase: a second class of SUMO protease."

"Other SUMO proteases, such as Ubiquitin‐Specific Peptidase‐Like protein 1 xref , DeSumoylating Isopeptidase 1 and DeSumoylating Isopeptidase 2 xref , have been identified but do not appear to be involved in changing global SUMOylation patterns."

"Hence, preventing deSUMOylation of USP5 could provide a strategy for enhancing USP5 interactions with Cav3.2, which would in turn be predicted to lead to analgesia."

"UBL-related DUBs also exist; for example, sentrin/SUMO-specific proteases (SENP), deSUMOylating isopeptidase (DeSI), and NEDD8-specific protease 1 (NEDP1) are targeted to SUMO and NEDD8, respectively [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

"In addition to the SENP family, de-SUMOylating isopeptidase 1 and 2 (DeSI1 and 2) and ubiquitin-specific protease-like 1 (USPL1) can also function as SUMO-protease."

"We acknowledge the caveat that a USP5 construct with a point mutation that prevents SUMOylation is not strictly equivalent to deSUMOylation of USP5."

"Members of the second family of SUMO proteases are desumoylating isopeptidase (DeSI) 1 and 2, which are primarily used for deconjugation of SUMO (reviewed in refs. xref , xref , xref )."

"Four IVI genes were significantly (p < 0.05) downregulated in T. bryosalmonae from infected kidney, compared to their expression in infected bryozoans: zinc finger CCHC domain-containing protein 10, gamma-aminobutyric acid receptor-associated protein, CD63 antigen, and casein kinase I. Additionally, non-significant (p = 0.40) upregulation of five IVI genes (14-3-3-like protein, iron-sulfur cluster assembly scaffold protein, peptidyl-prolyl cis-trans isomerase, S-methyl-5’-thioadenosine phosphorylase, and desumoylating isopeptidase 2) was also observed in the T. bryosalmonae from infected kidney compared to infected bryozoans."

"Moreover, we identified a SUMO protease, Capsicum annuum DeSUMOylating Isopeptidase 2 (CaDeSI2), as a new interacting partner of CaAITP1."

"Although the full name of DESI2 is desumoylating isopeptidase 2, up to now, there is no any report showing that it really has activities of desumoylating isopeptidase."