IndraLab

"DeSUMOylating isopeptidase: a second class of SUMO protease."

"Moreover, two additional SUMO isopeptidases have been described in humans, deSUMOylating isopeptidase (DeSI), and the ubiquitin-specific protease-like 1 (USPL1) ( xref ) [ xref ]."

"In addition to the SENP family, de-SUMOylating isopeptidase 1 and 2 (DeSI1 and 2) and ubiquitin-specific protease-like 1 (USPL1) can also function as SUMO-protease."

"We acknowledge the caveat that a USP5 construct with a point mutation that prevents SUMOylation is not strictly equivalent to deSUMOylation of USP5."

"Recently, several additional SUMO proteases have been identified, DeSumoylating Isopeptidase 1 and 2 (DeSI1 and DeSI2; Shin et al., xref ) and USPL1 (Ubiquitin-Specific Protease-Like 1; Schulz et al., xref )."

"Hence, preventing deSUMOylation of USP5 could provide a strategy for enhancing USP5 interactions with Cav3.2, which would in turn be predicted to lead to analgesia."

"Members of the second family of SUMO proteases are desumoylating isopeptidase (DeSI) 1 and 2, which are primarily used for deconjugation of SUMO (reviewed in refs. xref , xref , xref )."

"AMSH, associated molecule with the SH3 domain of STAM; AMSHLP, AMSH-like protease; ATXN3, ataxin 3; BAP1, BRCA1-associated protein 1; CEZANNE, cellular zinc finger anti-NF-κB protein; CSN, COP9 signalosome complex subunit; CYLD, cylindromatosis; DESI, desumoylating isopeptidase; EIF3, eukaryotic translation initiation factor 3; JAMM, JAB1, MPN, MOV34 family; JOSD, josephin domain; MINDY, motif-interacting with ubiquitin-containing novel DUB family; MJD, Machado–Josephin domain-containing protease; OTUD, OTU domain-containing protein; PRPF8, pre-mRNA-processing splicing factor 8; UCHL, ubiquitin carboxy-terminal hydrolase-like; USP, ubiquitin-specific protease; VCPIP1, valosin-containing protein p97/p47 complex-interacting protein 1."

"Other SUMO proteases, such as Ubiquitin‐Specific Peptidase‐Like protein 1 xref , DeSumoylating Isopeptidase 1 and DeSumoylating Isopeptidase 2 xref , have been identified but do not appear to be involved in changing global SUMOylation patterns."

"We also identified the following 6 genes as being co-expressed with the lncRNAs: myosin IG ( MYO1G ), translocase of inner mitochondrial membrane 29 ( TIMM29 ), co-activator associated arginine methyltransferase 1 ( CARM1 ), adhesion G protein-coupled receptor B1 ( ADGRB1 ), septin 4 ( SEPT4 ), and desumoylating isopeptidase 2 ( DESI2 )."