IndraLab

Statements

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"Namely, USP11 has been shown to promote the proliferation and metastasis of hepatocellular carcinoma (HCC), but the underlying molecular basis is poorly understood."
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"USP11 promotes the stability of IGF2BP3 to increase the colorectal cancer metastasis [99]."
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"Sun et al[26] also demonstrated that USP11 promotes the growth and metastasis of CRC via PPP1CA-mediated activation of the ERK/MAPK signaling pathway."
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"Taken together, these results indicate that the E2F1 and USP11 signal axis promotes HCC proliferation and metastasis and inhibits autophagy, which provides an experimental basis for the treatment of HCC."
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"We also demonstrated that overexpression of USP11 promoted proliferation and metastasis of CRC cells in vitro and in vivo, indicating that USP11 plays an important role in the development of CRC."
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"While USP11 is known to promote HCC metastasis and proliferation, the precise mechanisms, especially those related to cancer metabolism, remain unclear."
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"Higher levels of USP11 enhance lipogenesis, proliferation, and metastasis in HCC cells."
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"This suggested that USP11 promotes CRC invasion and metastasis."
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"USP11 potentiates HGF/AKT signaling and drives metastasis in hepatocellular carcinoma."
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"In vitro assays also verified that USP11 overexpression could enhance the invasive and metastasis capabilities of CRC cells, especially to the liver in vivo."
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"In colorectal cancer, USP11 promotes tumor growth and metastasis via the ERK/MAPK pathway by stabilizing PPP1CA [18]."
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"USP11 also regulates TGF-β-induced epithelial-mesenchymal plasticity and promotes human breast cancer metastasis by stabilizing TGF-βRII (78)."
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"For example, the aberrant expression of USP11 was found to interact with nuclear factor 90 and promote its deubiquitination, to promote the proliferation and metastasis of hepatocellular carcinoma."
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"Interestingly, the findings of another study indicated that USP11 promotes growth and metastasis by stabilizing PPP1CA in colorectal cancer, suggesting that DUBs could have opposite functions via regulating different proteins in diverse diseases25."
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"Additionally , USP11 could promote cell proliferation and metastasis via regulating nuclear factor 90 ( NF90 ) in hepatocellular carcinoma [ 37 ] ."
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"The E2F1 and USP11 positive feedback loop promotes hepatocellular carcinoma metastasis and inhibits autophagy by activating ERK and mTOR pathway."
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"In summary, these findings suggest that USP11 modulates lipid synthesis, growth, and metastasis in HCC cells via SREBF1."
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"Sheng Zhang et al. [86] identified that USP11 served as a marker of poor prognosis and promoted metastasis in hepatocellular carcinoma."
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"Overall, we suggest that USP11 promotes HCC cell metastasis, and we provide the first evidence of the prognostic significance of USP11 expression in HCC, which suggests that USP11 is a promising therapeutic target for the treatment of HCC."
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"In general, our results demonstrate that USP11 promotes HCC proliferation and metastasis through HIF-1alpha/LDHA-induced glycolysis, providing new insights and the experimental basis for developing new treatments for this patient population."
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"15 It has been demonstrated that USP11 promotes colorectal cancer and HCC growth and metastasis by stabilizing NF90 and activating the ERK/MAPK signalling pathway."
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"However, the precise mechanism by which USP11 promotes EMT and metastasis in hepatocellular carcinoma (HCC) is not fully understood."
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"Another study has the same point, namely, that the overexpression of USP11 promotes metastasis of CRC cells both in vitro and in vivo by activating the ERK/MAPK pathway and stabilizing PPP1CA."
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"Functional experiments demonstrated that USP11 markedly promoted metastasis and EMT in HCC via induction of the transcription factor Snail."
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"Changmao Zhang et al. [88] identified that USP11 promoted the proliferation and metastasis of hepatocellular carcinoma via deubiquitinating NF90, which was also proved to promote the proliferation and angiogenesis of cervical cancer."
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"We demonstrated that USP11 promotes EMT and metastasis in HCC via eEF1A1/SP1/HGF dependent-EMT."
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"USP11 promotes growth and metastasis of colorectal cancer via PPP1CA-mediated activation of ERK/MAPK signaling pathway."
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"USP11 promoted tumor growth and metastasis in CRC via the ERK/MAPK pathway by stabilizing PPP1CA, suggesting USP11 is a potential prognostic marker."
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"Daniel A. Garcia et al. [94] found that USP11 enhanced TGFβ-induced epithelial–mesenchymal plasticity and breast cancer metastasis."
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"On the other hand, USP11 significantly stimulates proliferation and metastasis of hepatocellular carcinoma cells both in vitro and in vivo [34]."
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"36 Combination and deubiquitination of USP11 to nuclear factor 90 (NF90) stabilized the protein expression and promoted HCC cell metastasis and proliferation."
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"USP11 promotes colorectal cancer growth and metastasis by stabilizing PPP1CA, activating the ERK/MAPK pathway, and insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) signaling (151), and interacting with nuclear factor 90 (NF90) to promote HCC proliferation and metastasis (152)."
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"USP11 promotes tumor growth and metastasis in CRC via the ERK/MAPK pathway by stabilizing PPP1CA[66,67]."
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"USP1, OUTB1, and USP11 induced migration, invasion, and metastasis through Snail (Figure 2B) [109,111,112]."
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"Additionally, USP11 could promote cell proliferation and metastasis via regulating nuclear factor 90 (NF90) in hepatocellular carcinoma [XREF_BIBR]."
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"More importantly, USP11 could promote cell growth and metastasis in colorectal cancer [XREF_BIBR, XREF_BIBR]."
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