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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Mutated NRAS activates KRAS. 2 / 2

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"Recent studies revealed that " minor " activating mutations such as those in KRAS codons 61 and 146, as well as NRAS mutations, contribute to resistance."

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"These included three activating NRAS mutations (NRAS , NRAS , NRAS ), which can drive active RAS signaling in a KRAS-independent manner, and BRAF , which can maintain MAPK signaling downstream of KRAS in the presence of MRTX849 (Supplementary Fig. S1)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...