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EGF leads to the phosphorylation of RPS6KA1. 12 / 12
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"RKTG expression inhibits EGF-stimulated ERK and RSK phosphorylation, blocks NGF-mediated PC12 cell differentiation, and antagonizes Ras- and Raf-1-stimulated Elk-1 transactivation."
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"The lack of endogenous RSK1 localization to the nucleus in the presence of Bimax1 was not due to changes in the ability of EGF to phosphorylate RSK1 on its various sites and activate it (Figure 3B)."
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"The data presented in xref D demonstrate that EGF induces phosphorylation of YB-1 and RSK in both cytoplasmic and nuclear fractions."
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"Pretreating cells with either compound inhibited EGF-stimulated RSK1 phosphorylation, with estimated IC 50 values of ∼500 nM for both ( Figure 2 F)."
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"Therefore, EGF induced RSK1 phosphorylation at the residues containing Ser-380 with/without Thr-573 (positions (a) and (b))."
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"Indeed, treating HEK293 cells with DEL-22379 prevented the phosphorylation of the cytoplasmic kinase RSK1 induced by EGF treatment while enhancing the transactivation of the transcription factor ELK t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Pretreating cells with either compound inhibited EGF stimulated RSK1 phosphorylation, with estimated IC 50 values of ~ 500 nM for both."
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"In the present study, EGF induced maximum increases in phosphorylation of both ERK1/2 MAPK and P90RSK and treatment of pTr cells with U0126 (pharmacological inhibitors for ERK1/2 MAPK activity) blocke[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Likewise, control experiments using the MAPK kinase (MAP2K) inhibitor UO126 suggest that EGF-stimulated phosphorylation of RSK1 in HeLa cells depends on the MAPK signaling axis (Figure S4)."
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"In contrast, ERK2(C159S) overexpression largely eliminated NAC-induced differences in RSK1 phosphorylation following EGF stimulation (Figure S5)."
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"EGF activates ERK phosphorylation of both RSK1 and RSK2 as expected ( xref )."
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"Based on the observation that DMF inhibited IL-1β, MIF and EGF induced phosphorylation of MSK1/2 and RSK1 kinases in keratinocytes xref , xref the theoretical binding sites of DMF at the C-terminal part of RSK2 kinase was investigated by X-ray crystallography."
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