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EGF leads to the phosphorylation of RPS6KA1. 11 / 12
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"RKTG expression inhibits EGF-stimulated ERK and RSK phosphorylation, blocks NGF-mediated PC12 cell differentiation, and antagonizes Ras- and Raf-1-stimulated Elk-1 transactivation."
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"The data presented in xref D demonstrate that EGF induces phosphorylation of YB-1 and RSK in both cytoplasmic and nuclear fractions."
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"Pretreating cells with either compound inhibited EGF-stimulated RSK1 phosphorylation, with estimated IC 50 values of ∼500 nM for both ( Figure 2 F)."
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"Therefore, EGF induced RSK1 phosphorylation at the residues containing Ser-380 with/without Thr-573 (positions (a) and (b))."
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"Indeed, treating HEK293 cells with DEL-22379 prevented the phosphorylation of the cytoplasmic kinase RSK1 induced by EGF treatment while enhancing the transactivation of the transcription factor ELK t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Pretreating cells with either compound inhibited EGF stimulated RSK1 phosphorylation, with estimated IC 50 values of ~ 500 nM for both."
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"In the present study, EGF induced maximum increases in phosphorylation of both ERK1/2 MAPK and P90RSK and treatment of pTr cells with U0126 (pharmacological inhibitors for ERK1/2 MAPK activity) blocke[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Likewise, control experiments using the MAPK kinase (MAP2K) inhibitor UO126 suggest that EGF-stimulated phosphorylation of RSK1 in HeLa cells depends on the MAPK signaling axis (Figure S4)."
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"In contrast, ERK2(C159S) overexpression largely eliminated NAC-induced differences in RSK1 phosphorylation following EGF stimulation (Figure S5)."
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"EGF activates ERK phosphorylation of both RSK1 and RSK2 as expected ( xref )."
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"Based on the observation that DMF inhibited IL-1β, MIF and EGF induced phosphorylation of MSK1/2 and RSK1 kinases in keratinocytes xref , xref the theoretical binding sites of DMF at the C-terminal part of RSK2 kinase was investigated by X-ray crystallography."
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