IndraLab

Statements

USP11 inhibits DNA repair. 2 / 2
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"More interestingly, whilst expression of USP11 rescued the defect in DNA repair induced by USP11 depletion, confirming the specificity of our siRNA sequences, expression of USP11-R433K could not, implying that methylation is required for USP11 to effectively function in the repair of olaparib-induced lesions (Fig. 4a, b)."
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"Additionally, USP11 depletion led to increased sensitivity to micrococcal nuclease following IR when compared to controls, and therefore may be able to modulate DNA repair factor access to chromatin as well [137]."
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