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BAP1 inhibits Neoplasms. 25 / 29
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"BAP1-inactivated melanocytic tumors represent a subset of epithelioid melanocytic neoplasms resulting from biallelic inactivation of the BAP1 gene and by a driver mutation that activate the MAP kinase pathway, most commonly BRAFV600E."
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"Fusions involved known tumor suppressors BAP1, MTAP, and LRP1B, and a clonal oncogenic fusion involving CACNA1D-ERC2, PARD3B-NT5DC2, and STAB2-NT5DC2 fusions were also identified as clonal fusions."
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"Zhang et al. showed that BAP1 inhibits tumor progression by promoting cellular ferroptosis ( 15 ) ."
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"BINs are highly penetrant, present in up to 90% of mutation carriers, and typically present as multiple, skin colored or reddish-brown, dome-shaped melanocytic tumors (also or previously called BAP1-inactivlated melanocytic tumors, Wiesner nevi, BAPomas, nevoid melanoma-like melanocytic proliferations, BAP1 mutant Spitz nevi, and melanocytic BAP1-mutated atypical intradermal tumors)."
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"Multiple Flesh-Colored Nodules: A Patient with Multiple BAP 1-Inactivated Melanocytic Tumors."
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"In vivo results using a chicken embryo choriollantoic membrane ( CAM ) assay showed that BaP1 inhibits tumor growth , angiogenesis , and tumor proliferation ."
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"As for MPM, next-generation sequencing of 216 MPM patients showed that the tumor suppressors BAP1, NF2, and SETD2 were significantly mutated through gene fusions and splicing alterations (Bueno et al., 2015)."
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"These cases demonstrate the importance of routine BAP1 tumor testing in meningioma with rhabdoid features regardless of grade, germline testing for patients with BAP1 inactivated tumors, and tailored cancer screening in this population."
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"Zhang et al. showed that BAP1 inhibits tumor progression by promoting cellular ferroptosis (15)."
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"Germline mutations in BAP1 predispose carriers to the BAP1 tumor predisposition syndrome (BAP1-TPDS), characterized by BAP1-inactivated nevi (BINs), uveal melanoma, cutaneous melanoma, mesothelioma, renal cell carcinoma, and other tumors."
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"The BAP1 gene encodes BRCA1-associated protein 1 , which suppresses tumors by promoting the activity of the Hippo tumor suppressor pathway [ 20 ] ."
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"C1 possessed more mutations in three well‐known tumor suppressors including TP53 and BAP1, while C2 possessed more mutations in genes CTNNB1, APOB1, and EEF1A1 (Figure 3d)."
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"Because germline mutations produce a TPDS, genetic testing should be offered to patients found to have BAP1 inactivated tumors."
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"A deterministic role for BAP1 has been shown in mice, where Bap1 loss induces more proliferative, higher-grade tumors (Gu et al., 2017)."
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"Novel insights into the BAP1-inactivated melanocytic tumor."
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"[[Translated article]]BAP1-inactivated Melanocytic Tumor: Dermoscopic Features to Aid Diagnosis."
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"Sometimes, ferroptosis contributed to the antitumour effects of the tumor suppressors such as p53 and BAP1."
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"Mutation analyses revealed that the high-CRRS HCC patients had a high mutational frequency of some tumor suppressors such as tumor protein P53 ( TP53 ) and Breast-cancer susceptibility gene 1 (BRCA1)-associated protein 1 ( BAP1 ) and a low frequency of catenin beta 1 ( CTNNB1 )."
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"BAP1-Inactivated Melanoma Arising From BAP1-Inactivated Melanocytic Tumor in a Patient With BAP1 Germline Mutation: A Case Report and Review of the Literature."
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"The knockdown of SLC7A11 in UMRC6 cells (a BAP1-deficient renal cancer cell line) marginally affects cancer cell proliferation, suggesting that the BAP1-mediated tumor suppression through regulating SLC7A11 [80]."
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"The addition of BAP1 loss increased tumor proliferation and melanoma size."
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"In vivo results using a chicken embryo choriollantoic membrane (CAM) assay showed that BaP1 inhibits tumor growth, angiogenesis, and tumor proliferation."
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"It is worth noticing that, through 3p loss, cancer cells also delete other important tumor suppressors such as VHL, SETD2,BAP1, and PBRM1."
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"The BAP1 gene encodes BRCA1-associated protein 1, which suppresses tumors by promoting the activity of the Hippo tumor suppressor pathway[20]."
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"BAP1-inactivated melanocytic tumor (BIMT) is a group of melanocytic neoplasms with epithelioid cell morphology molecularly characterized by the loss of function of BAP1, a tumor suppressor gene located on chromosome 3p21, and a mutually exclusive mitogenic driver mutation, more commonly BRAF."
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