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USP25 activates MYBPC1. 1 / 1

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"We showed that mutation of K99 clearly diminished USP25 dependent rescue of the specific substrate MyBPC1 from proteasome degradation, thereby supporting a new mechanistic model, in which USP25m is regulated through alternative conjugation of ubiquitin (activating) or SUMO (inhibiting) to the same lysine residue (K99), which may promote the interaction with distinct intramolecular regulatory domains."

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IndraLab

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USP25 activates MYBPC1. 1 / 1

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