IndraLab

Statements

reach
"SLO prevents phagolysosomal acidification."
25227466
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"In light of our findings that SLO is required to inhibit phagolysosome acidification, it is likely that SLO secreted by phagocytosed GAS forms pores in the phagolysosomal membrane and disrupts the proton gradient by permitting diffusion of solutes across the damaged membrane."
25227466
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"GAS bacteria are internalized by macrophage phagocytosis but resist killing by secreting SLO, which damages the phagolysosome membrane, prevents phagolysosome acidification, and translocates NADase from the phagolysosome into the macrophage cytosol."
25227466
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"GAS expression of SLO may impair macrophage phagolysosomal fusion and acidification, facilitate GAS escape from the phagosome into the cytoplasm, block autophagic and xenophagic killing, or activate the NLRP3 inflammasome and IL-1beta production and pyroptosis."
28769806
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"For a more quantitative assessment of the functional consequences of the production of small amounts of SLO on the intracellular fate of GAS, we also tested whether induction of SLO expression in 188SLO - (piSLO) inhibited the acidification of the bacterium containing vacuole, as observed for SLO producing strain 188."
21325037
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"Production of SLO prevented phagolysosomal acidification but was insufficient to support maximal GAS survival in the absence of enzymatically active NADase."
25227466
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"A recent report showed that SLO and NAD-glycohydrolase prevented phagolysosome acidification and promoted GAS survival in macrophages."
26419882
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"This mutant behaved similarly to the wild-type parent strain with respect to its failure to colocalize with LysoTracker, a result that suggests that SLO production, even in the absence of enzymatically active NADase, is sufficient to impair phagolysosomal acidification (XREF_FIG)."
25227466