IndraLab

Statements

USP1 binds WDR48 and BCHE. 5 / 5
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reach
"The E1, UAF1, and USP1 complex is necessary for efficient replication of HPV11 episomes in U2OS cells."
30890612
reach
"The E1, UAF1, and USP1 complex contributes to the generation of HPV11 RIs produced by unidirectional replication."
30890612
reach
"We conclude that the E1, UAF1, and USP1 complex supports the processing of late bidirectional theta RIs and propose that after the separation of bidirectional theta daughter genomes, the formerly converged replication forks undergo BLM mediated restart, thus initiating the unidirectional theta replication of HPV genomes."
30890612
reach
"The importance of the E1, UAF1, and USP1 complex for efficient HPV replication has been previously reported; however, we demonstrated that the lower replication efficiency of mutant HPV11 genomes encoding a E1 protein defective for UAF1 binding is associated with decreased production of RIs generated by the unidirectional mechanism, while bidirectional theta replication was affected to a lesser degree (XREF_FIG)."
30890612
reach
"Additionally, a role for the E1, UAF1, and USP1 complex in the processing of late bidirectional theta RIs would explain why defective E1, UAF1, and USP1 complex formation has no effect on the progression of theta and unidirectional replication forks (XREF_FIG)."
30890612