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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

SOS1 binds GRB2 and proline. 2 / 2

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"One LAT molecule is capable of binding up to three Grb2 molecules at a time andtwo Grb2 molecules bind one SOS1 or c-Cbl proline rich domain (XREF_FIG) 33."

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"Subsequently, two SH3 domains of GRB2 bind the proline rich SOS1 C-terminal tail (52-55), recruiting SOS1 to the cell membrane."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...