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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

EGF leads to the phosphorylation of STAT3 on S727. 3 / 3

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"Specific inhibition of ERK-1/2 activity blocked EGF- and BK induced STAT-3 activation and Ser 727 phosphorylation."

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"The addition of OSM and EGF induced the synergistic phosphorylation of STAT3 at Ser727 in wild-type astrocytes (XREF_FIG and Supplementary Fig. 5e)."

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"It was observed that inhibition of ERK½ by U0126 in HTR-8/SVneo cells resulted in concomitant inhibition of EGF-induced increase in STAT1 and STAT3 phosphorylation at ser 727 along with inhibition of degradation of total STAT1 (Figs xref and xref )."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...