IndraLab

Statements

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"Studies indicated that knockdown of USP18 causes an increased apoptosis of chronic myeloid leukaemia cells on interferon-alpha treatment [23]."
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"Silencing USP18 in SiHa and Caski cervical cancer cell lines inhibited cell proliferation, induced apoptosis, and promoted cleaved caspase-3 expression."
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"We then wanted to investigate if STAT1 is involved also in the downstream mechanisms by which ISG15, USP18, and IL-6, respectively, reduce neurogenesis and increase apoptosis."
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"We further showed that USP18 could reduce paclitaxol sensitivity, and attenuate paclitaxol-induced apoptosis and cell cycle arrest through activating autophagy in TNBC cells in vitro and in vivo ."
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"Overall, these results suggested that USP18 promotes pancreatic cancer cell proliferation by facilitating cell cycle progression and inhibiting cell apoptosis."
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"Of note, in contrast with IFN-alpha and IL-6, USP18 decreases apoptosis; this is consistent with previous evidence in brain ependymal cells."
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"USP18 could reduce paclitaxol sensitivity, and attenuate paclitaxol-induced apoptosis and cell cycle arrest through activating autophagy in TNBC cells."
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"Similar outcomes are obtained when USP18 is silenced in glioblastoma cells, which suggests that USP18 inhibition causes cells to undergo apoptosis with robust activation of caspase-8 and caspase-3 through enhancing the IFN-I pathway [176]."
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"Usp18 is induced by viral infection and type I interferons and inhibits apoptosis (Malakhova et al., 2006; Diao et al., 2020)."
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"Besides, USP18 silencing promoted the early apoptosis of HCC cells."
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"USP18 attenuates endoplasmic reticulum stress via the PERK-eIF2alpha-ATF4 axis to reduce apoptosis in hepatocellular carcinoma cells."
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"The upregulation of USP18 ameliorated hind limbs ' motor function , inhibiting inflammation and apoptosis after SCII in rats ."
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"Additionally, knockdown of USP18 inhibited the proliferation of HCC cells and induced G1 cell cycle arrest and early apoptosis."
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"Silencing of USP18 in hepatoma HepG2 cells was shown to cause accumulation of cells in G0/G1 and apoptosis 29."
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"Thus, we show that inhibition of USP18 exacerbates pro inflammatory chemokine production via induction of the STAT signaling pathway and increases IFN induced beta cell apoptosis by activation of the mitochondrial driven pathway of cell death."
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"Deubiquitinase Usp18 prevents cellular apoptosis from oxidative stress in liver cells."
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"In fact, USP18 knockdown contributes to IFN- and PIC induced caspases-9 and -3 activation and beta cell apoptosis."
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"Results showed that overexpression of USP18 attenuated apoptosis, whereas USP18 knockdown augmented apoptosis."
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"USP18 knockdown can promote the inflammatory response and apoptosis of pancreatic β cells induced by IFN, indicating that USP18 may be a suppressor gene in type 1 diabetes [165]."
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"Intriguingly, suppressed deISGylase USP18 sensitizes cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a potential molecule for anti-tumor treatment, and increased USP18[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Another RNA interference screen of 53 DUBs revealed that loss of USP18 enhanced apoptosis triggered by bortezomib or etoposide [XREF_BIBR]."
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"USP18 inhibited apoptosis via ER stress."
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"In fact, double inhibition of USP18 and STAT1 or STAT2 reverted the supportive effect of USP18 knockdown in IFNalpha induced beta cell apoptosis."
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"Subsequent work showed that knockdown of USP18 destabilized PML-RARalpha and promoted apoptosis in NB4 APL cells but did not have an effect on differentiation (Guo et al., 2010)."
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"USP18 overexpression facilitated proliferation and reduced apoptosis and oxidative stress in HUVECs treated with Ang in vitro."
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"Furthermore, cell apoptosis was promoted by USP18 silencing, and interference of USP18 suppressed cell migration and invasion."
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"Silencing of USP18 promoted PTX sensitivity by suppressing the proliferation and glycolysis and inducing apoptosis in PTX-resistant NSCLC cells."
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"The results of flow cytometry showed that knockdown of USP18 promoted apoptosis, the ER stress inhibitor 4-phenylbutyric acid (4-PBA) inhibited apoptosis, and knockdown of USP18 partially reversed the inhibitory effect of 4-PBA on apoptosis (Fig. 3a)."
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"Nevertheless, whether USP18 affects the apoptosis of HCC cells and the underlying mechanism for such an effect were previously unknown.In this study, we found that USP18 promoted the growth of HCC cell lines and suppressed apoptosis."
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"For instance , downregulation of USP18 reduces acute promyelocytic leukaemia cell growth and induces apoptosis , whereas silencing USP18 in glioblastoma cells enhances IFN-induced apoptosis [ 20 ] ."
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"Moreover, Overexpression of USP18 enhanced autophagy to inhibit cell apoptosis induced by SCII in vivo and in vitro."
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"USP18 also stabilize cyclin D of tumor cells to inhibit apoptosis [XREF_BIBR]."
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"In conclusion, the results of this study provide evidence that USP18 promotes growth and suppresses apoptosis of HCC cells, which might help to expand the research directions and clinical applications of USP18."
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"Knockdown of USP18 promoted apoptosis and ferroptosis of LUAD cells."
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"Treating Usp18 deficient hematopoietic cells with Poly I : C decreases the number of white blood cells since apoptosis is not prevented by USP18."
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"For example, ISG15/USP18 promotes the proliferation and inhibits the apoptosis of HBV-associated HCC cells [72]."
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"Overexpression of USP18 promotes cervical cancer cell proliferation and attenuates apoptosis by activating the PI3K/AKT signaling pathway [ 9 ]."
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"USP18 promotes cell proliferation and suppressed apoptosis in cervical cancer cells via activating AKT signaling pathway."
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"showed that USP18 contributed to proliferation and reduced apoptosis in cervical cancer [27]."
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"Loss of USP18 inhibits cell proliferation and increases apoptosis [XREF_BIBR]."
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"A study has indicated that USP18 contributes to controlling carcinogenesis, as loss of USP18 function increases apoptosis and decreases cell proliferation by destabilization of the cyclin D1 protein 22.It remains, however, unclear so far whether the EFP, HERC5 and USP18 genes contribute to tumourigenesis through ISG15/ISGylation or other mechanisms."
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"Previous studies demonstrated that USP18 plays a significant role in regulating autophagy: USP18 decreased paclitaxol sensitivity of triple-negative breast cancer via promoting autophagy [26]; USP18 overexpression could promote autophagy to inhibit cell apoptosis induced by spinal cord ischemia–reperfusion injury [27]; USP18 stabilizes cGAS through deubiquitination, enhancing autophagy in melanoma cells and thereby promoting resistance to vemurafenib in BRAF V600E mutant melanoma [28]."
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"USP18 inhibition by two independent siRNAs increased beta cell apoptosis following exposure to IFNalpha or IFNgamma (XREF_FIG), whereas siCTRL has no such effect."
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"Furthermore, Silencing USP18 inhibits the proliferation and increases apoptosis of pancreatic cancer cells [ 11 ]."
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"USP18 could diminish apoptosis and cell cycle arrest of TNBC induced by paclitaxol."
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"On the other hand, the upregulation of USP18 inhibits beta cell apoptosis."
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"Importantly, USP18 overexpression could effectively attenuated paclitaxol-induced apoptosis (from 29.6% to 23.2%) ( Fig. 2 B)."
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"Engineered reduction of USP18 expression repressed lung cancer growth and promoted apoptosis."
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"Moreover, it was also found that USP18 knockdown significantly induced the apoptosis of U251 and U87MG ATCC cells (Fig. 7D)."
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"In addition, compared with control cells, USP18 knockdown increased paclitaxol-induced apoptosis (from 29.8% to 37.7%), induced G2/M phase arrest (from 14.64% to 19.09%), and decreased S phase proport[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Subsequently, we demonstrated that knockdown of USP18 inhibited HCC cell growth and caused cell-cycle arrest and early apoptosis."
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