IndraLab

Statements

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"Overall, these results suggested that USP18 promotes pancreatic cancer cell proliferation by facilitating cell cycle progression and inhibiting cell apoptosis."
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"Silencing of USP18 in hepatoma HepG2 cells was shown to cause accumulation of cells in G0/G1 and apoptosis 29."
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"Moreover, Overexpression of USP18 enhanced autophagy to inhibit cell apoptosis induced by SCII in vivo and in vitro."
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"Deubiquitinase Usp18 prevents cellular apoptosis from oxidative stress in liver cells."
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"In fact, double inhibition of USP18 and STAT1 or STAT2 reverted the supportive effect of USP18 knockdown in IFNalpha induced beta cell apoptosis."
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"Silencing USP18 in SiHa and Caski cervical cancer cell lines inhibited cell proliferation, induced apoptosis, and promoted cleaved caspase-3 expression."
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"Engineered reduction of USP18 expression repressed lung cancer growth and promoted apoptosis."
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"Thus, we show that inhibition of USP18 exacerbates pro inflammatory chemokine production via induction of the STAT signaling pathway and increases IFN induced beta cell apoptosis by activation of the mitochondrial driven pathway of cell death."
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"Another RNA interference screen of 53 DUBs revealed that loss of USP18 enhanced apoptosis triggered by bortezomib or etoposide [XREF_BIBR]."
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"Furthermore, cell apoptosis was promoted by USP18 silencing, and interference of USP18 suppressed cell migration and invasion."
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"On the other hand, the upregulation of USP18 inhibits beta cell apoptosis."
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"USP18 overexpression reduced paclitaxol sensitivity by decreasing paclitaxol-induced apoptosis and cell cycle arrest in TNBC cells."
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"Moreover, our experimental data revealed that USP18 silencing obviously blocked cell cycle at G1 phase and increased cell apoptosis."
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"We then wanted to investigate if STAT1 is involved also in the downstream mechanisms by which ISG15, USP18, and IL-6, respectively, reduce neurogenesis and increase apoptosis."
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"USP18 inhibition by two independent siRNAs increased beta cell apoptosis following exposure to IFNalpha or IFNgamma (XREF_FIG), whereas siCTRL has no such effect."
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"A study has indicated that USP18 contributes to controlling carcinogenesis, as loss of USP18 function increases apoptosis and decreases cell proliferation by destabilization of the cyclin D1 protein 22.It remains, however, unclear so far whether the EFP, HERC5 and USP18 genes contribute to tumourigenesis through ISG15/ISGylation or other mechanisms."
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"USP18 also stabilize cyclin D of tumor cells to inhibit apoptosis [XREF_BIBR]."
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"In fact, USP18 knockdown contributes to IFN- and PIC induced caspases-9 and -3 activation and beta cell apoptosis."
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"Treating Usp18 deficient hematopoietic cells with Poly I : C decreases the number of white blood cells since apoptosis is not prevented by USP18."
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"USP18 promotes cell proliferation and suppressed apoptosis in cervical cancer cells via activating AKT signaling pathway."
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"Subsequently, we demonstrated that knockdown of USP18 inhibited HCC cell growth and caused cell-cycle arrest and early apoptosis."
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"83 The absence of USP18 in the breast cancer cell line MCF-7 results in an increase in the induction of apoptosis by chemotherapy and treatment with IFN-α.27 Silencing USP18 in glioblastoma cells produces similar results,84 a finding suggesting that strengthening the IFN-I pathway by silencing USP18 elicits apoptosis in drug-treated cells with robust caspase-8 and caspase-3 activation independent of the mitochondrial pathway.27The direct effect of USP18 on tumor progression has been studied with leukocytes."
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"For example, ISG15/USP18 promotes the proliferation and inhibits the apoptosis of HBV-associated HCC cells [72]."
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"Subsequent work showed that knockdown of USP18 destabilized PML-RARalpha and promoted apoptosis in NB4 APL cells but did not have an effect on differentiation (Guo et al., 2010)."
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"The upregulation of USP18 ameliorated hind limbs ' motor function , inhibiting inflammation and apoptosis after SCII in rats ."
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"Besides, USP18 silencing promoted the early apoptosis of HCC cells."
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"Of note, in contrast with IFN-alpha and IL-6, USP18 decreases apoptosis; this is consistent with previous evidence in brain ependymal cells."
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"27 Silencing USP18 in glioblastoma cells produces similar results, 84 a finding suggesting that strengthening the IFN-I pathway by silencing USP18 elicits apoptosis in drug-treated cells with robust caspase-8 and caspase-3 activation independent of the mitochondrial pathway."
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"Studies indicated that knockdown of USP18 causes an increased apoptosis of chronic myeloid leukaemia cells on interferon-alpha treatment [23]."
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"For instance , downregulation of USP18 reduces acute promyelocytic leukaemia cell growth and induces apoptosis , whereas silencing USP18 in glioblastoma cells enhances IFN-induced apoptosis [ 20 ] ."
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"Loss of USP18 inhibits cell proliferation and increases apoptosis [XREF_BIBR]."
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