IndraLab

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Ezogabine activates KCNQ5. 9 / 9
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dgi
No evidence text available
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"In the present study, retigabine enhanced the KCNQ5 current at -30 and -60 mV, by 3 and 7 fold, respectively."
11890900
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"The preference for KCNQ4 activation was in contrast to GABA and gabapentin, which we previously found to each activate only KCNQ3 and KCNQ5, and to retigabine which favors KCNQ3 and activates KCNQ2, KCNQ4 and KCNQ5 to a lesser extent, and does not activate KCNQ1 ."
31701029
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"Moreover, KCNQ3 and KCNQ5 channels are potently activated by the anticonvulsant retigabine (Wickenden et al., 2001)."
12890507
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"KCNQ5 can be activated and inhibited by the specific KCNQ5 channel activator Retigabine and inhibitor XE991, which were selected to continue the in vitro cell experiment."
35002772
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"Recently, Wickenden et al. (2001) have also shown that retigabine can activate the KCNQ5 and KCNQ3 heteromer expressed in CHO cells."
11890900
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"Retigabine activated the KCNQ5 channel by increasing the current in a concentration dependent way."
11890900
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"Retigabine has been the most characterized activator of KCNQ channels and has been shown to potentiate KCNQ2, KCNQ3, KCNQ4, and KCNQ5, without activating KCNQ1, thereby avoiding potential cardiac effects [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
33801540
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"In addition, the possible effects of form deprivation on potassium ionic currents and the pharmacological sensitivity of KCNQ5 activator Retigabine and inhibitor XE991 to the M-current in RPE cells were investigated using the patch-clamp technique."
35002772