IndraLab

Statements

UCHL5 activates Ubiquitin. 10 / 10
| 10
reach
"RPN11 and POH1 has been demonstrated to cleave at the base of the ubiquitin chain, removing ubiquitin en masse, while UCH37 and USP14 mediate a stepwise removal of ubiquitin from the substrate starting from the distal end."
23291607
reach
"RPN11 cleaves at the base of the ubiquitin chain where it is linked to the substrate, whereas UCH37 and apparently USP14 mediate a stepwise removal of ubiquitin from the substrate by disassembling the chain from its distal tip."
20823120
reach
"UPS14 and UCH37 are thought to mediate stepwise disassembly of the Ub chain from the distal end 6 ."
26041011
reach
"However, as UCHL5 and USP14 are proposed to mediate a stepwise removal of ubiquitin from the substrate by trimming the chain from its distal tip, this leaves the opportunity for MGRN1 to reach a monou[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28475871
reach
"We, therefore, wanted to determine the type of the ubiquitin linkage targeted on Tcf7 by Uch37."
28198400
reach
"It appears that POH1 cleaves at the base of the ubiquitin chain where it is linked to the target protein, whereas USP14 and UCHL5 mediate a stepwise removal of ubiquitin from the protein by disassembling the chain from its distal tip [XREF_BIBR]."
26097878
reach
"The deeper mechanism may be that the degradation of β-catenin depends on the UCHL5-mediated ubiquitin–proteasome pathway."
32596150
reach
"The western blot results showed that inhibition of both UCHL5 and USP14 by b-AP15 significantly increased the accumulation of polyubiquitinated proteins by 31.80 +/- 6.25% (P = 0.008, n = 5) and reduc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29407217
reach
"RPN11 appears to cleave at the base of the ubiquitin chain, where it is linked to the substrate, whereas USP14 and UCHL5 are known to mediate stepwise removal of ubiquitin from the substrate by disassembling the chain from its distal end [XREF_BIBR]."
21995438
reach
"Once bound by the proteasome, deubiquitinating enzymes, like the 19S subunit Rpn11 [XREF_BIBR, XREF_BIBR] or proteasome associated Ubp6 [XREF_BIBR, XREF_BIBR] and Uch37 [XREF_BIBR, XREF_BIBR], remove the ubiquitin moiety to allow recycling of ubiquitin before degradation of the substrate."
32759676