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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TGFB1 bound to TGFBR2 increases the amount of TGFBR1 bound to TGFBR2. 1 / 1

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bel

"from Figure 1 - Fig 1. The transforming growth factor beta (TGF-b) signaling pathway. TGF-b binds type II TGF-b receptor (TbRII), directly or through TbRIII, inducing association of TbRII with TbRI. TbRII then phosphorylates and activates TbRI, which then phosphorylates Smad2 or Smad3. Phosphorylated Smad2 or Smad3 associates with Smad4 and they translocate into the nucleus, where they activate transcription of target genes. Smad7 inhibits TGF-b signaling by preventing the activation of Smad2 or Smad3 by TbRI."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...