IndraLab

Statements


USP28 deubiquitinates CLSPN. 4 / 4
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"Claspin is a bona fide USP28 substrate, as Claspin deubiquitination by USP28 could also be reconstituted in vitro."

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"Thus, USP28 deubiquitinates Claspin to enable the activation of a CHK1-dependent G -checkpoint , and protects checkpoint-mediators to facilitate apoptosis ."

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"De-ubiquitinase USP28 inhibits ubiquitination of Claspin protein and its proteasomal degradation [XREF_BIBR]."