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USP7 activates cell cycle. 13 / 13
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"Taken together, our results suggest that loss of USP7 function inhibits the melanoma cell cycle and promotes cell apoptosis by mediating AMPK and PI3K/Akt/FOXO signaling pathway activity."
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"In this regard, Usp7 inhibition or depletion has been shown to impair cell cycle progression and proliferation also in a p53- independent manner by regulating genome stability and repair 69,88,89."
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"The overexpression of USP7 leads to changes in DNA damage response, apoptosis and cell cycle, thus causing tumor progression."
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"Concomitantly , USP7 downregulation significantly arrested the cell cycle , increasing the proportion of A375 cells in the G1 phase and decreasing the proportion in the S phase ( Figures 2G , H ) ."
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"In this study, we demonstrated that loss of USP7 function inhibits cell growth by promoting cell cycle arrest and apoptosis in A375 and B16 cells."
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"Our results indicate that inhibition of USP7 leads to a disruption of cell cycle progression , and triggers DNA damage and apoptosis ."
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"The essential role of USP7 during cell cycle progression and apoptosis has been reported by other groups : i ) USP7 knockdown leads to increased p53 expression and arrest of cell cycle ( Cummins et al ., 2004 ) , ii ) USP7 regulated various tumor-related factors expression ( p53 , Ki-67 ) in bladder cancer and prostate cancer ( Song et al ., 2008 ; Morra et al ., 2019 ) ."
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"Overexpression of USP7 was found to inhibit the ERK1/2 signaling pathway and induce cell cycle delay."
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"As shown in Figures 5 E and S6 D, USP7 knockdown suppressed cell cycle progression, reducing the percentage of S phase cells (from 32.9% to 13.6%), whereas RRM2 restoration significantly reversed the [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Further , we found that USP7 inhibitor inhibited tumor proliferation via promoting the stability of P53 in GC and arrested the cell cycle at G2-M phase ."
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"68 On another hand, overexpression of TRIP12 (R SILAC = 1.62) produces inhibition of USP7, which is an ubiquitin specific processing protease whose depletion induce cell cycle arrest at the S phase."
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"Overexpression of USP7 has been found to result in increased p53 stabilization and therefore increased cell cycle arrest and apoptosis XREF_BIBR."
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"We did not detect increased γH2AX level in shUSP7-depleted or P5091-treated cells.In this work, we demonstrate that USP7 mediates cell cycle progression regulating RRM2 protein expression."
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