IndraLab

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MTOR phosphorylates IRS1 on serine. 24 / 24
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"Additionally, p70 S6K, the downstream effector of mTOR, has been shown to cause serine phosphorylation of IRS-1, resulting in impaired insulin signaling and insulin resistance [XREF_BIBR]."
32230718
rlimsp
"The activation of mTOR phosphorylates its downstream protein ribosomal S6 protein kinase (S6K), participating in several processes including protein synthesis and proliferation [12], [13]. It became apparent that serine phosphorylation of IRS1 reduces the ability of IRS1 to activate PI3K [10]–[12]."
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"In vitro studies with rapamycin suggest that mTOR and S6K1 overactivation contributes to elevated serine phosphorylation of IRS-1, leading to impaired insulin signaling to Akt in liver and muscle of this dietary model of obesity."
15604215
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"Notably, hyperactive S6K1 and mTOR negatively regulate Akt by inducing IRS-1 serine phosphorylation (S302 (human 307) [XREF_BIBR], S636/639 [XREF_BIBR], S1101 [XREF_BIBR], S307 (human 312) [XREF_BIBR, XREF_BIBR]), which disrupts its interaction with the insulin receptor, and results in degradation."
27376324
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"Activation of mTOR signaling pathway has been found to suppress insulin sensitivity through serine phosphorylation and the inhibition of IRS1 by mTOR and its downstream effector, S6K1."
18949383
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"This impairment correlated with increased phosphorylation of mTOR, p70S6K and serine phosphorylation of IRS-1 [XREF_BIBR]."
32230718
sparser
"The mammalian target of rapamycin (mTOR) is downstream of Akt and can phosphorylate IRS1 on serine residues, targeting it for degradation ( xref )."
19236051
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"Reduced mTOR and S6K1 signaling during chronic increases in physical activity may play an important regulatory role in the serine phosphorylation of IRS-1, which should be examined as a potential mechanism for attenuation of insulin resistance associated with increased IRS-1 serine phosphorylation."
18347658
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"MTOR induced the serine phosphorylation of IRS-1 (Ser 636/639), and such phosphorylation was inhibited by rapamycin."
11287630
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"In a similar fashion, it was shown that rapamycin induced mTOR inhibition decreased the serine phosphorylation of IRS-1, which was associated with a compensatory IGF-I downstream signaling via the PI3K and AKT pathway [XREF_BIBR]."
27661006
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"Overfeeding and metabolic stresses, including high levels of free fatty acids or inflammatory cytokines, enable activation of a number of endogenous protein kinases, such as mTOR, JNK, and IKKbeta, which can phosphorylate IRS1 and IRS2 at serine and threonine residues and which mediate IRS protein ubiquitination and degradation, resulting in insulin resistance [XREF_BIBR]."
24015152
trips
"mTOR induced the serine phosphorylation of IRS-1 (Ser-636/639), and such phosphorylation was inhibited by rapamycin."
11287630
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"MTOR, along with other kinases such as JNK, phosphorylate IRS-1 on serine residues, leading ultimately to IRS-1 degradation."
23123443
sparser
"Given that dietary protein and amino acids can impair insulin signaling through mammalian target of rapamycin complex 1/S6 kinase 1 (mTORC1/S6K1) dependent phosphorylation of insulin receptor substrate 1 (IRS1) on multiple inhibitory serines residues xref – xref , we next tested whether our PM diet impacts metabolic health via this nutrient-sensing mechanism."
34099716
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"TNF-alpha produced by obesity induced inflammation stimulates IKK XREF_BIBR, JNK XREF_BIBR, and mTOR and S6K XREF_BIBR XREF_BIBR, which enhance serine phosphorylation of insulin receptor substrate-1 (IRS-1)."
26316333
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"Recent studies demonstrate that the mTOR downstream target S6K1 directly phosphorylates IRS1 serine residues, including Ser 302/307, Ser 307/312, Ser 632/636, and Ser 1097/1101."
21282364
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"Studies conducted in rodent models and cultured rat myocytes found that increased exposure of skeletal muscle cells to BCAA impairs insulin action in concert with activation of the mammalian target of rapamycin (mTOR), which causes serine phosphorylation of insulin receptor substrate-1 and disrupts insulin signaling."
23610059
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"Activation of the cell nutrient sensor mTOR and S6K1 kinase causes serine phosphorylation of IRS-1, with a subsequent decline in the IRS1-associated PI3K activity."
35212998
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"However, by also inhibiting an mTOR dependent serine phosphorylation of insulin receptor substrate-1 (IRS-1), they may enhance insulin like growth factor-I (IGF-I) signaling and downstream phosphatidylinositol 3-kinase (PI3K)/AKT activation."
16227402
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"Other feedback or alternative signaling loops that mediate resistance involve an mTOR dependent serine phosphorylation of insulin receptor substrate-1 (IRS-1) that enhances insulin like growth factor-1 (IGF-1) signaling leading to downstream activation of PI3K and AKT."
23714559
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"The mammalian target of rapamycin (mTOR) is downstream of Akt and can phosphorylate IRS1 on serine residues, targeting it for degradation."
19236051
reach
"Once activated by insulin, mTOR and p70S6K phosphorylates insulin receptor substrate-1 (IRS-1) on serine residues, resulting in its inhibition and reduction of insulin signaling."
21602475
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"Accordingly, the inhibition of mTOR by rapamycin was found to attenuate serine phosphorylation of IRS-1, restore insulin action on the PI3K and AKT pathway and prevent the insulin resistant effects of excess nutrients on insulin mediated glucose transport in muscle and adipose cells XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR."
26449763
reach
"A previous study demonstrated that increased activation of mTOR and S6 kinase beta-1 (S6K1) may promote serine phosphorylation of IRS-1, thus resulting in the pathogenesis of hepatic insulin resistance in obese rats."
27909723