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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Reactive oxygen species inhibits UCHL1. 3 / 3

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"As predicted, using the DUB activity UbVME probe, we showed that UCH-L1, a Cys dependent DUB belonging to the UCH family is also inhibited by ROS, like USP2, albeit to a different extent (XREF_FIG)."

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"USP14 activity is not regulated by its redox state [21], whereas UCH-L1 is inactivated by ROS, at least in vitro [20,21]."

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"USP14 activity is not regulated by its redox state [ xref ], whereas UCH-L1 is inactivated by ROS, at least in vitro [ xref , xref ]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...