IndraLab

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VCPIP1 activates VCP. 4 / 4
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"Next, we wanted to ascertain whether VCIP135 contributes to p97 and p47 mediated membrane fusion using an in vitro Golgi reassembly assay."
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"The deubiquitinase VCIP135, which is associated with the p97 and p47 complex, removes the ubiquitin moiety and thus allows p97 and p47 to fuse the membranes after mitosis (XREF_FIG) 37."
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"Considering that the disassembly of the p97, p47, and SNARE complex by VCIP135 requires ATP hydrolysis (XREF_FIG E), we suggest that the function of VCIP135 in membrane fusion is to mediate the dissociation of the p97, p47, and SNARE complex, which may be part of the SNARE priming process."
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"As shown in XREF_FIG G, VCIP135 partially prevented alpha-SNAP binding to GST-syn5DeltaTM, suggesting that VCIP135 directs syntaxin5 to p97 and p47 but not to alpha-SNAP and NSF."
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