IndraLab

Statements

VCPIP1 activates VCP. 5 / 5
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reach
"VCPIP1 S130 was phosphorylated by Cdk1 in early mitosis and then inactivated to block the P97/VCP‐P47 mediated Golgi membrane fusion."
39234822
signor
"Golgi biogenesis requires two distinct p97ATPase-mediated membrane fusion, the p97/p47 and p97/p37 pathways. |We clarified that VCIP135, an essential factor in both p97 membrane fusion pathways, is phosphorylated on Threonine-760 and Serine-767 by Cdc2 at mitosis and that this phosphorylated VCIP135 does not bind to p97."
23500464
reach
"30 , 31 Our structure indicates that the binding of VCPIP1 to the D2 domain of P97/VCP would induce a conformational change, promoting P97/VCP into the NTDs “UP” state."
39234822
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"22 Consistently, our studies have demonstrated that VCPIP1 biochemically promotes P97/VCP‐p47 binding to SNARE substrates, the addition and binding of WAC protein to VCPIP1 might further stimulate their binding for membrane fusion.Recently, VCPIP1 has been reported to associate with both the N‐ and C‐terminal regions of P97/VCP via its C‐ and N‐terminal regions, respectively."
39234822
reach
"In particular, as p47, p37, Ufd1, and VCIP135 share the same p97-binding motif (SHP motif), it is reasonable that VCIP135 may induce the dissociation of complexes of p97 with p47, p37, and Ufd1."
38072049