IndraLab

Statements

VCPIP1 activates VCP. 4 / 5
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"VCPIP1 S130 was phosphorylated by Cdk1 in early mitosis and then inactivated to block the P97/VCP‐P47 mediated Golgi membrane fusion."
39234822
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"30 , 31 Our structure indicates that the binding of VCPIP1 to the D2 domain of P97/VCP would induce a conformational change, promoting P97/VCP into the NTDs “UP” state."
39234822
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"22 Consistently, our studies have demonstrated that VCPIP1 biochemically promotes P97/VCP‐p47 binding to SNARE substrates, the addition and binding of WAC protein to VCPIP1 might further stimulate their binding for membrane fusion.Recently, VCPIP1 has been reported to associate with both the N‐ and C‐terminal regions of P97/VCP via its C‐ and N‐terminal regions, respectively."
39234822
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"In particular, as p47, p37, Ufd1, and VCIP135 share the same p97-binding motif (SHP motif), it is reasonable that VCIP135 may induce the dissociation of complexes of p97 with p47, p37, and Ufd1."
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