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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TRAF binds USP7 and MDM2. 2 / 2

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"Conversely, the TRAF domain and C-terminal (amino acids 801–1050) of USP7 can interact with MDM2 and increase its stability by removing ubiquitin from MDM2, an E3 ligase of p53, preventing its degradation [ xref ]."

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"On the other hand, TRAF domain and C-terminal (amino acids 801–1050) of USP7 can interact with MDM2 to increase its stability by erasing the ubiquitin on MDM2, an E3 ligase of p53 ( xref ), and protect it from proteasome degradation."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...