IndraLab

Statements

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"We report here that CO reliably and repeatedly activates Slo1 BK channels in excised membrane patches in the absence of Ca (2+) in a voltage-sensor-independent manner."
18316727
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"CO enhances maxi K channel activity in glomus cells."
22664830
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"Carbon monoxide (CO), which is another endogenous like NO, can increase native BK channel activity."
25346693
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"XREF_BIBR Therefore, the conformational changes in the BK channel protein induced by CO may resemble those by Ca 2+ and H+; XREF_BIBR, XREF_BIBR, XREF_BIBR CO increases the gate open probability without requiring activation of the VSDs."
24556640
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"It has been further suggested that CO, along with NO, can also directly augment BK channel activity when applied at sufficiently-high concentrations."
25202279
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"Heme-oxygenase-2 (3b), which is tightly associated with cell membrane BK channels (4b), uses O 2 as a substrate to produce carbon monoxide (CO), which enhances BK channel open probability during normoxia."
22982216
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"Thus CO stimulates the BK channel activity even when the concentrations of these free multivalent cations are negligible."
24556640
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"What is noteworthy is that CO, a gaseous messenger akin to nitric oxide (NO), increases the BK channel activity in different systems (Perez-Garcia et al., 2000; Wang and Wu, 1997; Xi et al., 2004)."
16137743
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"Thus the role of maxiK channel activation by CO as a physiological means by which CO acts as an inhibitory gasotransmitter remain to be resolved."
24382871
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"Heme-oxygenase-2 (3b), which is tightly associated with cell membrane BK channels (4b), uses O 2 as a substrate to produce carbon monoxide (CO), which enhances BK channel open probability during normoxia."
22982216
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"Because of the rapid reversibility of CO and cyanide binding, they proposed that CO activates the Slo1 BK Ca channel by binding to a transition metal cluster 62."
28474046
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"Furthermore, CO was able to mimic the effects of HO-2 substrate provision and augment maxiK channel activity several-fold."
24382871
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"In contrast, CO repeatedly stimulates the human Slo1 BK Ca channel opening possibly by binding to an unknown iron site because cyanide prohibits this heme independent CO stimulation."
28474046
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"Carbon monoxide (CO), which is another endogenous like NO, can increase native BK channel activity."
25346693
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"Their data corroborate previous findings of Wang et al. (Wang et al., 1997b) who showed that the effect of gaseous CO on K channels was not mediated by cGMP, but contradict the findings of De Backer et al. (De Backer and Lefebvre, 2007) in which CO mediated relaxation in circular smooth muscle strips of the murine gastric fundus and jejunum was sGC and BK channel dependent."
34552483