IndraLab

Statements

USP4 deubiquitinates PTP4A3. 6 / 6
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"Mechanistically, we observed that USP4 interacted with and stabilized PRL-3 via deubiquitination."
26669864
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"USP4 can also deubiquitylate PRL-3 to lead to AKT activation, E-cadherin reduction, and distant metastasis [30]."
38134227
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"In CRC tissues, USP4 has been found to stabilize PRL-3 by deubiquitinating PRL-3, activating PI3K/AKT pathway and down-regulating E-cadherin, thereby promoting tumor proliferation and metastasis (Xing et al., 2016)."
37251574
ubibrowser
"28279784"
28279784
reach
"Deubiquitinating PRL-3 by USP4 leads to AKT activation and E-cadherin reduction in colorectal cancer, where an elevated level of USP4 is associated with tumor size, differentiation, distant metastasis, and poor survival."
33681193
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"Specifically, up-regulated USP4 potentiated the growth and invasion of colorectal cancer though deubiquitination and stabilization of PRL-3.19 In addition, USP4 transduced Akt activation to TGF-beta signalling by deubiquitinating and stabilizing TGF-beta type I receptor, thus augmented breast cancer cell invasion and migration.33 These studies demonstrate USP4 as a powerful tumour promoter and an important determinant for canonical oncogenic signalling."
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