IndraLab

Statements

PTEN inhibits PDPK1. 10 / 10
| 1 9
reach
"PTEN and SHIP prevent activation of PDK, upstream of p-Akt308."
33780466
reach
"Loss of PTEN leads to increased PDK1 and AKT due to PIP3 accumulation resulting in activation of mTORC1 and its downstream effectors [XREF_BIBR]."
23434669
eidos
"Therefore , PTEN deficiency activates the PDK1 / mTORC2 ( Sin1 ) - AKT axis , subsequently phosphorylating SNAP23 and enhancing alpha-granule secretion of platelets ."
35589797
reach
"On the other hand, the lipid phosphatase PTEN deactivates PDK1 by transforming PIP 3 to PIP 2."
29104535
reach
"In PTEN disrupted cells, PDK1, AKT, and PKCzeta exhibited elevated basal activities, which prevented EGF induced further activation of these molecules."
17761400
reach
"PTEN deletion thus induces the growth and proliferation of T cell progenitors independently of PDK1."
19808258
reach
"Therefore, PTEN deficiency activates the PDK1/mTORC2(Sin1)-AKT axis, subsequently phosphorylating SNAP23 and enhancing α-granule secretion of platelets.We next sought to ask whether Pten-deficient platelets regulate Tfh cell differentiation."
35589797
reach
"PTEN functions as a lipid and protein phosphatase, inhibiting the ability of PDK1 to activate AKT."
29724995
reach
"PI3K promotes while PTEN (phosphatase and tensin homology) inhibits the activities of downstream PDK1 (3-phosphoinositide-dependent protein kinase-1) and AKT (or PKB, protein kinase B)."
30100999
reach
"A surprising result is that PTEN deletion results in strong activation of PDK1 and PKB, but bypasses the normal PDK1 requirement for cell growth and proliferation of T cells."
19808258