IndraLab

Statements

Proteasome deubiquitinates UCHL5. 5 / 5
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"Furthermore, direct interaction of PSMD8 has been reported with the proteasome associated deubiquitinating enzyme UCH37 (Li et al., 2001)."
20004025
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"Additional targets which play a role in WM cell survival include TLR7, 8 and 9, proteasome associated deubiquitinating enzymes (USP14 and UCHL5), XPO1 and CRM1 and AURKA."
27825468
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"Furthermore, since deubiquitinating enzymes associated with the proteasome are responsible for ubiquitin trimming from substrates targeted to the proteasome for degradation, and in light of growing evidence that the manner in which proteasome associated deubiquitinating enzymes, USP14 and UCH37, deubiquitinate substrates can in fact suppress and delay degradation and modulate proteasome function, we decided to next analyze the functional activity of the proteasome associated deubiquitinating enzyme USP14."
23291607
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"B-AP15 simultaneously inhibits the proteasome associated deubiquitinating enzymes UchL5 and Usp14, whereas RA190 binds and inhibits the ubiquitin receptor subunit Rpn13 [XREF_BIBR, XREF_BIBR]."
25385277
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"Recently, we reported that the proteasome associated deubiquitinating enzyme UCHL5 and Uch37 is a new prognostic marker in both rectal cancer and pancreatic ductal adenocarcinoma."
29474458