IndraLab

Statements

AR is glycosylated. 29 / 29
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"In addition, the glycosylation of α 2c -ARs was not required for appropriate folding to a functional confirmation, since each of the glycosylation deficient α 2c -AR constructs were determined to be functional by radioligand binding."
20059747
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"Taken together, the immunofluorescence, FACS analysis, and endoglycosidase experiments suggest that asparagine-linked glycosylation of α 2c -ARs is not the predominate mechanism responsible for the distinct trafficking behavior observed for the α 2c -ARs."
20059747
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"In line with our previous study [ xref ], GalNAc‐T2 was found to be the major isoform controlling hβ 1 AR O‐glycosylation."
39206632
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"In the Steinberg group’s first major foray into βAR glycosylation, Park et al xref determined that β 1 AR O-glycosylation at Ser 37 /Ser 41 inhibited N-terminal cleavage."
37719428
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"Since the β 2 AR N-terminus is glycosylated due to the presence of two asparagine-dependent glycosylation sites xref , we examined whether these N-glycan chains might be important for receptor activation by N. meningitidis ."
31628314
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"To further characterize hβ 1 AR O‐glycosylation and to validate the in vitro findings, we determined O‐glycosites from the native receptor purified from HEKSimpleCells transfected with the S49 and T29 variants."
39206632
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"Taken together, these data indicate that two of the tested polymorphisms, A29T and S49G, alter hβ 1 AR O‐glycosylation."
39206632
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"Further, they demonstrated that the full-length glycosylated β 1 AR as well as a truncated O-glycosylation–defective mutation were both competent to signal via the PKA and MAPK pathways."
37719428
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"We have previously shown that GalNAc‐T2 is the major driver of β 1 AR O‐glycosylation modulating the limited proteolysis of the WT receptor in cultured cells and in the rat heart ventricles in vivo [ xref ]."
39206632
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"Interestingly, a polymorphic variation of β 1 AR Ser49Gly known to have differential signaling properties and a potential site of O-linked glycosylation does not appear to substantially affect the overall β 1 AR glycosylation profile. xref "
37719428
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"The mechanism study suggested that the key pathway of ortho -C Ar -H glycosylation might undergo oxidative addition/reduction elimination, while aryl meta -C-H glycosylation was mediated by σ -activation strategy."
35674418
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"Here we demonstrate that the polypeptide GalNAc-transferase 2 (GalNAc-T2) specifically O -glycosylates β 1 AR at five residues in the extracellular N terminus, including the Ser-49 residue at the location of the common S49G single-nucleotide polymorphism."
28167537
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"To further study the effect of Rab43 on the ER-Golgi transport of GPCRs, we measured the effect of Rab43 on the conversion from simple to complex N-linked glycosylation of α 2A -AR and AT1R."
29069590
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"Therefore, we mapped β 1 AR glycosylation sites and determined whether β 1 ARs glycosylation prevents β 1 AR cleavage."
28801655
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"All ARs are also glycosylated on the second extracellular loop, though this does not necessarily modulate ligand affinity."
23764371
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"We found that the alpha(1B)-AR undergoes N-linked glycosylation as demonstrated by its sensitivity to endoglycosidases and by the effect of tunicamycin on receptor maturation."
11914074
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"N-Linked glycosylation of the alpha(1B)-AR occurs at four asparagines on the N-terminus of the receptor."
11914074
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"Our findings indicate that the Semliki Forest virus system can provide large amounts of functional and fully glycosylated alpha(1B)-AR protein suitable for biochemical and structural studies."
11914074
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"The aforementioned post-translational glycosylation of ARs, which may vary in a cell type-dependent fashion, likely accounts for these discrepancies."
10722120
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"The small amount of REEP1/2/6 co-localization with α2C ARs ( xref ), most likely represents the site of interaction of the minimally glycosylated form, which is a minor contributor to the total pool of mature and immature glycosylated α2C ARs, possibly accounting for the low amount of co-localization seen."
24098485
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"We recently identified a similar immunoreactive profile for this transgene in 2 different model cell lines and showed that the ∼69-kDa species corresponds to FL fully glycosylated β 1 ARs; the ∼55-kDa species corresponds to N-terminally truncated glycosylation-defective β 1 ARs xref ."
30175276
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"We examined the potential glycosylation of Flag-tagged β 1 AR heterologously expressed in HEK-293 cells, which do not express endogenous β 1 AR."
12270132
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"Phosphorylation or glycosylation of the AR complex may result in activation by way of inhibition or prevention of rebinding of the chaperones."
24759590
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"To determine if Asn15 is the only site of β 1 AR N-linked glycosylation, we performed enzymatic deglycosylation studies."
12270132
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"These data reveal that blocking β 1 AR N-linked glycosylation impairs β 1 AR dimerization."
12270132
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"Our data indicate, however, that the action of Con A on blocking β 1 AR internalization is a direct effect mediated via association of Con A with the carbohydrate portion of the receptor, since the N1[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12270132
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"Therefore, while glycosylation of the beta AR does not appear to be essential for receptor function, it is important for correct trafficking of the beta AR protein through the cell."
2162359
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"It is likely that the glycosylation of α 2c -ARs improves overall receptor biosynthesis and trafficking to the PM by increasing the efficiency of protein folding."
20059747
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"We have previously demonstrated that hβ 1 AR is O‐glycosylated at five sites in its N‐terminus."
39206632