IndraLab

Statements

KCNE binds KCNQ1. 8 / 8
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"In light of the structural studies that KCNE3 imposes a counterclockwise rotation of the whole VSD relative to the PD of KCNQ1 channels and functional studies that KCNE1 most likely shares a similar location with KCNE3 in the KCNQ1/KCNE complex , we propose that KCNE1 rotates the VSD towards to the PD of KCNQ1."
34285340
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"While for neither protein does the N-terminus appear to be critical for dictating the channel-modulatory properties, the N-terminus is known to affect the pH sensitivity and pharmacological properties of the assembled KCNE and KCNQ1 complex."
20044833
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"1 The channel associates with KCNE beta subunits that enforce prominent changes in the KCNQ1 (minK) current kinetics, which is likely one of the reasons for KCNQ1 and KCNE complexes being capable of p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22024150
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"The allosteric gating features, from this point of view, open what we believe to be a new perspective for reevaluation of KCNQ1 and KCNE complex regulation both in heterologous expression systems and [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21320432
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"Structures of the KCNQ1-KCNE complex are, therefore, eagerly awaited."
31236320
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"Overall, the results indicate that, along with homomeric KCNQ1, various KCNQ1/KCNE complexes are regulated by external K ."
36809486
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"Activation of ATP sensitive P2Y4 receptors leads to phosphorylation and de-activation of the KCNQ1 and KCNE complex, thus decreasing potassium secretion into scala media and consequently lowering the hair cell sensory transduction driving force."
20109547
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"Our results and those of earlier studies (Larsen et al., 2011; Wang et al., 2015) show that the extent of the K -dependent regulation of KCNQ1/KCNE complexes may depend on the type and the quantity of the associated β subunits."
36809486