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NAV1 activates SCN1A. 1 / 1

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"This appears to be a case in which a channelopathy produces an interneuronopathy since NaV1.1 (the protein product of Scn1a) is localized to the axon initial segments of parvalbumin positive (Pv +) fast spiking and Somatostatin positive (SST) interneurons in the neocortex and hippocampus, as well as to purkinje neurons of the cerebellum, which also exhibit fast spiking behavior."

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IndraLab

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NAV1 activates SCN1A. 1 / 1

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