IndraLab

Statements

CYLD inhibits TP53. 5 / 6
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"The role of CYLD in regulating p53 is evolutionarily conserved as shown by our findings that CYLD deficiency impairs p53 dependent DNA damage induced germ cell apoptosis in C. elegans."
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"We did not directly address the specific role of the proteasome in mediating CYLD induced degradation of p53, as any experiment involving proteasome inhibition would result in p53 stabilization and thus would be inconclusive in proving the specific role of CYLD."
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"Therefore, lack of CYLD catalytic activity inhibited the p53 dependent death of IECs in response to DNA damage in vivo and in vitro."
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"By stabilizing p53 and interaction with FZR1, the reversal of CYLD overexpression suppressed PFKFB3 expression via two different pathways, thereby inhibiting glucose metabolism, lactate secretion, and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In the presence of MG132, Flag-CYLD remarkably decreased ubiquitin chains of p53 ( Fig. 4 J, Supplementary Fig. S5H )."
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