IndraLab

Statements

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"This strategy is not unique to viruses because the bacterial virulence factor YopJ also functions as a DUB that inhibits TRAFsmediated innate immune response [35] ."
18957937
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"To assess whether DUB-negative mutants indeed induce a stronger 374 innate immune response than wt rMERS-CoV, mRNA levels of IFN-β, IFIT2, and viperin in infected 375 cells were measured by real-time RT-qPCR."
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"Importantly, we have recently been able to show that the DUB activity of EAV PLP2 inhibits the innate immune response in infected cells, via the structure-based design of a viable mutant virus lacking this activity (van Kasteren et al., 2013)."
25975520