IndraLab

Statements

RAF1 phosphorylated on S259 is inactive. 13 / 13
2 11 |
signor
"Akt and protein kinase a (pka) phosphorylate s259 on raf-1 and inhibit its activity."
16854453
signor
"serines 43, 259, and 621 are phosphorylated by PKA in vitro and induced by cAMP in vivo.cAMP increased Raf-1 serine 259 phosphorylation in a PKA-dependent manner with kinetics that correlated with ERK deactivation."
11971957
signor
"Akt and protein kinase a (pka) phosphorylate s259 on raf-1 and inhibit its activity."
10576741
signor
"We have identified a complex comprised of Shoc2/Sur-8 and the catalytic subunit of protein phosphatase 1 (PP1c) as a highly specific M-Ras effector. M-Ras targets Shoc2-PP1c to stimulate Raf activity by dephosphorylating the S259 inhibitory site of Raf proteins"
16630891
biopax:pid
No evidence text available
12048182
signor
"The stage-specific inhibitory action of Akt correlated with its stage-specific ability to form a complex with Raf, suggesting the existence of differentially expressed mediators of an inhibitory Akt-Raf complex."
10576741
signor
"Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras. Cyclic AMP (cAMP) blocks Raf-1 activation by stimulating its phosphorylation on serine 43 (Ser43), serine 233 (Ser233), and serine 259 (Ser259)."
12801936
biopax:pid
No evidence text available
10576742
signor
"Mutation of serine 259 increased the basal raf-1 activity and rendered it largely resistant to inhibition by pka."
11971957
signor
"... the PP2A holoenzymes ABC and ABC act downstream of Ras and upstream of MEK1 to promote activation of this MAPK signaling cascade. Furthermore both PP2A holoenzymes were found to associate with Raf1 and catalyze dephosphorylation of inhibitory phospho-Ser-259."
16239230
signor
"Mutation of serine 259 increased the basal raf-1 activity and rendered it largely resistant to inhibition by pka."
11971957
signor
"... the PP2A holoenzymes ABC and ABC act downstream of Ras and upstream of MEK1 to promote activation of this MAPK signaling cascade. Furthermore both PP2A holoenzymes were found to associate with Raf1 and catalyze dephosphorylation of inhibitory phospho-Ser-259."
16239230
signor
"Akt and protein kinase a (pka) phosphorylate s259 on raf-1 and inhibit its activity."
16854453