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EGFR activates MAPK1. 27 / 74
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"Here we demonstrate that EGFR-activated ERK2 binds directly to PKM2 I429/L431 via the ERK2 docking groove and phosphorylates PKM2 Ser37 but not PKM1."
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"Furthermore, the nuclear translocation of PKM2 could also be induced by EGFR-activated ERK2, and PKM2 is phosphorylated at S37 without the phosphorylation of PKM1, which recruits PIN1 for cis–trans isomerization of PKM2 and promotes the binding to importin α5 and nuclear translocation of PKM2."
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"EGFR-activated ERK2 phosphorylates PKM2 at Ser37, which recruits PIN1 for cis-trans isomerization of PKM2, promotes PKM2 binding to importin α5, and translocating to the nucleus subsequently followed with enhancement of transcription and expression of GLUT1 and LDHA (Yang et al., xref )."
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"To explore the possibility that the MAPK1 E322K mutation may have paradoxically conferred exquisite dependency on aberrant EGFR signaling in this patient, wild-type MAPK1 (CAL-33) and MAPK1 E322K (HSC-6) HNSCC cells were analyzed for relative EGFR protein and pathway activation (XREF_FIG)."
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"Consistent with this hypothesis, our data showed that while wild type ArhGAP9 significantly suppressed Erk2 or p38alpha activity induced by EGFR, the mutants of ArhGAP9 that was defective in binding to the MAP kinases resulted in only marginal suppression of EGFR induced MAP kinase activation."
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"Interestingly, inhibiting EGFR with PD153035 in Comma D cells did not prevent activation of Erk1 and Erk2 by EGF."
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"Constitutive p42 and ERK2 activity is abrogated by blockade of the EGF receptor."
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"AG1478, a specific EGF receptor kinase inhibitor, abolished the prolonged erk-1 and erk-2 activation produced by EGF in cells pretreated with BAPTA/AM."
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"Yang et al. found that PKM2 Ser 37 is phosphorylated by EGFR-activated ERK2, and phosphorylated PKM2 recruits PIN1 for cis-trans isomerization of PKM2 [20] ."
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"PKM2 is directly bound with EGFR-activated extracellular signal-regulated kinase 2 (ERK2) at PKM2-specific exon 10-encoded Ile 429/Leu 431 through ERK2 docking groove, and is phosphorylated at Ser 37."
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"In chicken undifferentiated granulosa cells, stimulation of TGFbeta1 on FSHR transcription is abrogated via activation of ERK2 by the EGF receptor ligands (e.g. TGFalpha, betacellulin) [XREF_BIBR], whereas, temporal activation of ERK2 is required for TGFalpha or betacellulin induced TGFbeta1 expression which implicates ERK2 mediated expression of MAPK phosphatases [XREF_BIBR, XREF_BIBR]."
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"Yang et al. demonstrate that EGFR-activated ERK2 binds directly to PKM2 through the ERK2 docking groove and phosphorylates PKM2 at Ser 37 ( xref )."
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"Taking together, it seems that the EGFR-induced ERK2 activation at G,/S boundary of cell cycle after the HgClg- induced renal injury contribute to the induction of cyclin D being required for the p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Here we provide evidence that prostaglandin E2 (PGE2) rapidly phosphorylates EGFR and triggers the extracellular signal regulated kinase 2 (ERK2) -- mitogenic signaling pathway in normal gastric epithelial (RGM1) and colon cancer (Caco-2, LoVo and HT-29) cell lines."
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"As an illustrative example, although PKM (pyruvate kinase) was not a K-BMAPS hit, EGFR-activated ERK2 directly phosphorylates Ser37 of the PKM2 isoform, promoting nuclear localization and, thereby, cell cycle progression, Warburg effect, and tumorigenesis. xref Identification of substrates and interactors of PKM and the other kinases suggests activation of downstream signaling pathways after EGF stimulation."
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"[XREF_BIBR] EGFR activated extracellular signal regulated kinase 2 (ERK2) binds PKM2 and phosphorylates PKM2."
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"Protein concentrations were determined by a bicinchoninic acid (BCA) protein assay (Pierce, Rockford, IL, USA) and samples were stored at -80 degreesC until used for immunoblotting and in vitro kinase[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"With respect to a role of EGFR mediated ERK2 activation during the regenerative process, it still remains to be clarified."
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"For example, EGFR-activated ERK2 promotes nuclear translocation and protein kinase activity of PKM2 (Yang et al., xref ; Yang et al., xref )."
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"HNSCC cell lines overexpress EGFR and ErbB2 receptors, which activate ERK1 and ERK2 [XREF_BIBR - XREF_BIBR]."
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"Taking together, it seems that the EGFR induced ERK2 activation at G,/S boundary of cell cycle after the HgClg- induced renal injury contribute to the induction of cyclin D being required for the prog[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Acid wash was therefore a potent inactivator of upstream stimulation of ERK2 by EGFR."
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"Additionally, EGFR-activated ERK2 can bind and activate CK2α ( xref )."
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"In estrogen stimulation of lung cancer cells, EGFR ligands are rapidly released, activating the EGFR and mitogen activated protein kinase 1 growth pathways."
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"These results indicate that TC45 can inhibit the Delta EGFR mediated activation of ERK2 and suppress the tumorigenicity of Delta EGFR expressing glioblastoma cells in vivo."
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"WT prostasin reduced the protein and mRNA levels of EGFR and dramatically reduced activation of Erk2, indicating that expression of prostasin in PC-3 cells abrogates the activity of the EGFR and MAPK signaling pathway."
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"The administration of albumin infusion and normal protein diet to hypoalbuminemic rats before or after surgical insertion was demonstrated to increase the activity of EGFR, which, in turn, induces ERK1 and ERK2 signaling that subsequently activates NF-kappaB pathways associated with the expression of proteins such as albumin, TGF-beta, MMP-8, and collagen."
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