IndraLab

Statements

KCNMA1 activates IL1B. 9 / 9
| 9
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"Once again, flagellin delivered with SLO induced IL-1beta even when the K + gradient was collapsed."
24829412
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"We found that SLO induced IL-1beta in a dose dependent manner (XREF_FIG A), starting at concentrations similar to those that induced pyroptosis."
23744055
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"In agreement with previously published data, a strain deficient for SLO expression (Deltaslo) did not activate the inflammasome, and IL-1beta release induced by SLO competent bacteria in BMDMs was dependent on the inflammasome components caspase-1, Nlrp3, and ASC (XREF_FIG), but not the sensors Naip5 (NLR family, apoptosis inhibitory protein 5) or Nlrc4 (NLR family, CARD domain containing 4) (XREF_FIG)."
28720729
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"GAS expression of SLO may impair macrophage phagolysosomal fusion and acidification, facilitate GAS escape from the phagosome into the cytoplasm, block autophagic and xenophagic killing, or activate the NLRP3 inflammasome and IL-1beta production and pyroptosis."
28769806
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"Caspase-11-deficient and C57BL/6 (B6) macrophages secreted similar amounts of IL-1beta in response to GAS infection, indicating that IL-1beta secretion induced by SLO is completely caspase-1 dependent (XREF_FIG)."
28720729
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"No significant extracellular IL-1beta secretion was induced by SLO treatment alone of hCFs (~ 0.7 pg/mL, data not shown)."
28469996
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"To demonstrate that both SLO and SLO N402C were triggering inflammasome dependent IL-1beta secretion, we treated LPS primed Casp1 -/- BMDM with SLO or SLO N402C and measured IL-1beta secretion by ELISA."
23744055
reach
"Unexpectedly, we found that lipopolysaccharide (LPS)-primed BMDMs (XREF_FIG and XREF_SUPPLEMENTARY), as well as similarly primed macrophages derived from the human monocytic cell line THP-1 (XREF_FIG), infected with the nga (G330D) mutant strain secrete significantly increased levels of IL-1beta than cells infected with the wt bacteria (wt infected cells) do, suggesting a role for this toxin as a negative regulator of SLO mediated IL-1beta release."
28720729
reach
"We believe that the results showing that KCa1.1 and KCa3.1 activators promote IL-1beta secretion are not due to off-target effects."
28507328