IndraLab

Statements

SQSTM1 binds CYLD. 27 / 27
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reach
"CYLD, a de-ubiquitinating enzyme, physically interacts with p62, the CYLD and TRAF6 complex negatively regulates TRAF6 ubiquitination and regulates the sustained inhibitory actions of NF-kB and NFATc1 during RANKL induced osteoclastogenesis."
33842470
reach
"XREF_BIBR, XREF_BIBR Interestingly, there is also evidence that p62 interacts with CylD, which suggests a potential dual role of p62 in regulating not only the ubiquitination and subsequent activation of NF-kappaB signaling intermediaries but also its inactivation by deubiquitination through CylD."
19713972
sparser
"CYLD, a de-ubiquitinating enzyme, physically interacts with p62, the CYLD/TRAF6 complex negatively regulates TRAF6 ubiquitination and regulates the sustained inhibitory actions of NF-kB and NFATc1 during RANKL-induced osteoclastogenesis ( xref ). xref demonstrated that Sesn2 interacts with Keap1, p62, and ubiquitin ligase and that the antioxidant activity of Sesn2 is mediated by activation of Nrf2 and p62-dependent autophagic degradation of Keap1 when ROS is increased as a result of an increase in mTORC1 activity and ER stress due to environmental stresses."
33842470
biogrid
No evidence text available
19201866
sparser
"As diagrammed in xref , whereas the p62-TRAF6 interaction was found immediately after IFN-γ/TLR stimulation, this interaction was largely replaced by the p62-CYLD interaction in a later stage, indicating that TRAF6 ubiquitination, triggered upon stimulation, was reversed at a later time, coinciding with the recruitment of CYLD."
19201866
reach
"Two recent studies have shown that the adaptor protein p62 (also named sequestosome 1) binds to CYLD and recruits it to TRAF6."
19373246
sparser
"To gain functional insight into the late interaction of p62 with CYLD, we examined ubiquitination of total p62- associated proteins following stimulation."
19201866
sparser
"Adaptor protein p62 binds to CYLD and recruits it to TRAF6 [ xref ]."
28031783
reach
"Moreover, p62, which interacted with TRAF6 in an early stage, interacted with CYLD, the deubiquitinating enzyme to the p62 complex, in a later stage."
19201866
sparser
"CYLD binds the scaffolding protein and autophagy receptor p62 [ xref ], which is also abundant in the PSD."
32709994
sparser
"Interestingly, we found that CYLD interacted physically with the signaling adaptor p62 and thereby was recruited to TRAF6."
18382763
reach
"CYLD interacts with p62 directly and CYLD can directly inactivate HDAC6, thereby controlling autophagy [XREF_BIBR]."
25342597
reach
"CYLD binds the scaffolding protein and autophagy receptor p62 [103], which is also abundant in the PSD."
32709994
sparser
"CYLD interacts with p62 directly and CYLD can directly inactivate HDAC6, thereby controlling autophagy [ xref ]."
25342597
sparser
"In xref , the interaction of p62 with CYLD was also seen in a reciprocal Co-IP after IFN-γ/ CpG stimulation."
19201866
reach
"These results reinforce the notion that p62, upon IFN-gamma and CpG induction, interacted with CYLD and inhibited TRAF6 autoubiquitination, leading to the negative regulation of NF-kappaB activity in macrophages."
19201866
reach
"The authors found that CYLD interacts directly with the adaptor protein p62 and is recruited to TRAF6 thereby leading to its deubiquitination and subsequent inhibition."
23468073
sparser
"Two recent studies have shown that the adaptor protein p62 (also named sequestosome 1) binds to CYLD and recruits it to TRAF6. xref , xref Whether p62 also recruits CYLD to other molecules is not known."
19373246
reach
"P62 interacts with CYLD and promotes the binding of CYLD to TRAF6, and this molecular interplay requires the C-terminal domain of p62 [XREF_BIBR]."
22216904
biogrid
No evidence text available
19201866
sparser
"Here, we report that CYLD binds with the p62 wild-type (p62WT), non-UBA mutant (p62A381V) but not with the UBA mutant (p62P392L) in OCL progenitor cells."
21878516
sparser
"Thus, we examined the interaction of CYLD with p62 and autoubiquitination of TRAF6 following IFN-γ/CpG stimulation in RAW cells."
19201866
reach
"Adaptor protein p62 binds to CYLD and recruits it to TRAF6 [XREF_BIBR]."
28031783
sparser
"P62 interacts with CYLD and promotes the binding of CYLD to TRAF6, and this molecular interplay requires the C-terminal domain of p62 [ xref ]."
22216904
reach
"It has been shown that p62 and sequestosome1 binds to TRAF6 through its UBD and recruits CYLD to TRAF6 to regulate its ubiquitination XREF_BIBR, XREF_BIBR."
21408173
sparser
"The authors found that CYLD interacts directly with the adaptor protein p62 and is recruited to TRAF6 thereby leading to its deubiquitination and subsequent inhibition."
23468073
reach
"It has been shown that p62 and sequestosome1 binds to TRAF6 through its UBD and recruits CYLD to TRAF6 to regulate its ubiquitination XREF_BIBR, XREF_BIBR."
21408173