IndraLab

Statements

HCN1 activates PEX5L. 3 / 3
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"However, the effects of HCN1 DeltaSNL and HCN1 DeltaCX diverged when tested against TRIP8b (1b-2); surprisingly, truncation of the entire HCN1 extreme C-terminus restored the capacity of TRIP8b (1b-2) to fully abolish channel surface expression."
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"In the medial perforant path, which normally contains HCN1 channels in axon terminals in immature but not in adult rodents, we found axonal HCN1 significantly increased in adult mice lacking TRIP8b (TRIP8b -/-)."
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"To examine how reduction in TRIP8b causes loss of Ih, we used immunohistochemistry to examine the expression and localization of HCN1 protein (the predominant HCN isoform in pyramidal neurons) following siRNA mediated knockdown of TRIP8b."
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